Русский
Risk factors for the development of various subtypes of gestational diabetes mellitus
DOI: https://dx.doi.org/10.18565/therapy.2022.10.63-71
Volkova N.I., Davidenko I.Yu., Sorokina Yu.A., Degtyareva Yu.S.
Rostov State Medical University of the Ministry of Healthcare of Russia, Rostov-on-Don
Objective: to establish risk factors for the development of various subtypes of GDM.
Materials and methods. 130 pregnant women were examined without a history of carbohydrate metabolism disorders. According to the Matsuda index, the subjects were divided into: group I – 45 pregnant women with GSD and β-cell dysfunction, group II – 43 pregnant women with GSD and IR, group III – 42 pregnant women without GSD (control). The study examined risk factors whose contribution to the development of GSD is already well known, as well as factors that, in our opinion, can influence the development of GSD. Carbohydrate metabolism was evaluated. The data were considered statistically significant at p <0,05.
Results. Pregnant women with GDM and IR are characterized by an older age at the onset of pregnancy (p=0,009), signs of acanthosis nigricans (p=0,03), the weight of the first child at birth (p=0,047), a large body weight, rarer intake of folic acid and low physical activity before pregnancy (p <0,001). Patients with GDM and β-cell dysfunction are characterized by a younger age, lack of regular MC before pregnancy (p=0,02), lower body weight and BMI (p <0,001) and more frequent use of folic acid (p=0,048). Both groups of patients were characterized by the absence of pre-gravidar preparation (p=0,03).
Conclusion. We have found that in addition to the influence of the patient’s age and body weight before pregnancy, low physical activity and lack of pregravidar preparation have an important contribution to the development of various subtypes of GDM.
Literature
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About the Autors
Natalya I. Volkova, Dr. med. habil., professor, head of the Department of internal diseases No. 3, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane. E-mail: dim3@rostgmu.ru
Ilya Yu. Davidenko, PhD in Medicine, associate professor of the Department of internal diseases No. 3, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane. E-mail: Davidenko.iu@gmail.com
Yulia A. Sorokina, assistant at the Department of internal diseases No. 3, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane
Yulia S. Degtyareva, assistant at the Department of internal diseases No. 3, Rostov State Medical University of the Ministry of Healthcare of Russia. Address: 344022, Rostov-on-Don, 29 Nakhichevansky Lane
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