Prediabetes: Therapy of carbohydrate metabolism disorders in patients with risk factors


DOI: https://dx.doi.org/10.18565/therapy.2024.9.163-168

Malyavin A.G., Mkrtumyan A.M., Adasheva T.V., Bolieva L.Z.

1) Russian University of Medicine of the Ministry of Healthcare of Russia, Moscow; 2) A.S. Loginov Moscow Clinical Research Center of the Department of Healthcare of Moscow; 3) North Ossetian State Medical Academy of the Ministry of Healthcare of Russia, Vladikavkaz
Abstract. Article considers the key issues of management of patients with early carbohydrate metabolism disorders at the primary outpatient healthcare level. The most important tasks at this stage of medical care include increasing the detection of prediabetes during preventive medical examinations and health surveys, active recommendations to patients on lifestyle modification, as well as timely prescription of pharmacotherapy. Drugs used in this case should affect various pathological mechanisms of the development of carbohydrate metabolism disorders, helping to control insulin resistance, glycemia, prevent the transformation of prediabetes into type 2 diabetes mellitus and prevent complications.
Keywords: impaired fasting glucose, Subetta, impaired glucose tolerance, prediabetes, metformin, insulin resistance
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Literature

1. Федеральный регистр больных с сахарным диабетом. Доступ: https://sd.diaregistry.ru/content/o-proekte.html#content (дата обращения – 28.10.2024). (The Federal Register of patients with diabetes mellitus. URL: https://sd.diaregistry.ru/content/o-proekte.html#content (date of access – 28.10.2024) (In Russ.)).


2. Федеральная служба государственной статистики. Росстат изучил рацион россиян. Доступ: https://rosstat.gov.ru/folder/313/document/70761 (дата обращения – 28.10.2024). (Federal State Statistics Service. Rosstat has studied the diet of Russians. URL: https://rosstat.gov.ru/folder/313/document/70761 (date of access – 28.10.2024) (In Russ.)).


3. Diabetes Atlas 10th edition. URL: https://diabetesatlas.org/idfawp/resource-files/2021/07/IDF_Atlas_10th_Edition_2021.pdf (date of access – 28.10.2024).


4. International Diabetes Federation. Diabetes Atlas, 2021. URL: https://diabetesatlas.org/atlas/tenth-edition (date of access – 28.10.2024).


5. Перечень поручений по итогам встречи с членами Общероссийской общественной организации «Деловая Россия». Сайт Президента России. Доступ: http://www.kremlin.ru/acts/assignments/orders/68298 (дата обращения – 28.10.2024). (The list of instructions following the meeting with members of the All-Russia Public Organization “Business Russia”. The website of the President of Russia. URL: http://www.kremlin.ru/acts/assignments/orders/68298 (date of access – 28.10.2024) (In Russ.)).


6. Шестакова М.В., Драпкина О.М., Бакулин И.Г. с соавт. Диагностика, лечение и диспансерное наблюдение пациентов с предиабетом в условиях первичной медико-санитарной помощи. Методические рекомендации Минздрава России. 2021. Доступ: https://gnicpm.ru/wp-content/uploads/2020/08/minzdrav_prediabet.pdf (дата обращения – 28.10.2024). (Shestakova M.V., Drapkina O.M., Bakulin I.G. et al. Diagnosis, treatment and follow-up of patients with prediabetes in primary health care. Methodological recommendations of the Ministry of Healthcare of Russia. 2021. URL: https://gnicpm.ru/wp-content/uploads/2020/08/minzdrav_prediabet.pdf (date of access – 28.10.2024) (In Russ.)).


7. Приказ Минздрава России от 15.03.2022 № 168н «Об утверждении порядка проведения диспансерного наблюдения за взрослыми». Доступ: http://publication.pravo.gov.ru/Document/View/0001202204210027 (дата обращения – 28.10.2024). (Order of the Ministry of Healthcare of Russia dated March 15, 2022 No. 168n “On approval of the procedure for conducting dispensary supervision of adults”. URL: http://publication.pravo.gov.ru/Document/View/0001202204210027 (date of access – 28.10.2024) (In Russ.)).


8. Аметов А.С. Современные аспекты патогенеза сахарного диабета 2 типа: β-клетка, что с тобой? Эндокринология: новости, мнения, обучение. 2022; 11(4): 8–20. (Ametov A.S. Modern aspects of type 2 diabetes mellitus pathogenesis: β-cell, what’s wrong with you? Endokrinologiya: novosti, mneniya, obuchenie = Endocrinology: News, Opinions, Training. 2022; 11(4): 8–20 (In Russ.)).


https://doi.org/10.33029/2304-9529-2022-11-4-8-20. EDN: FZDXOF.


9. Saleh A.M. People with diabetes adherence to drug, dietary, and lifestyle changes in Erbil city, Iraq. BMC Endocr Disord. 2022; 22(1): 305.


https://doi.org/10.1186/s12902-022-01230-0. PMID: 36476604. PMCID: PMC9727943.


10. Государственный реестр лекарственных средств Минздрава России. Инструкция по применению лекарственного препарата для медицинского применения Глюкофаж. РУ: П N014600/01 от 13.08.2008. Доступ: https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=1d92d621-9c62-45d9-94f5-67622e0df0a2 (дата обращения – 28.10.2024). (State Register of Medicines of the Ministry of Healthcare of Russia. Instructions for use of the medicinal product for medical use Glucophage. Registration certificate: П N014600/01 dated 08/13/2008. URL: https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=1d92d621-9c62-45d9-94f5-67622e0df0a2 (date of access – 28.10.2024) (In Russ.)).


11. Государственный реестр лекарственных средств Минздрава России. Инструкция по применению лекарственного препарата для медицинского применения Субетта. РУ: ЛП-№(000028)-(РГ-RU) от 18.12.2019. Доступ: https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=1c2e38fc-4204-4e5b-9839-48f134266015 (дата обращения – 28.10.2024). (State Register of Medicines of the Ministry of Healthcare of Russia. Instructions for use of the medicinal product for medical use Subetta. Registration certificate: ЛП-№(000028)-(РГ-RU) dated 12/18/2019. URL: https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=1c2e38fc-4204-4e5b-9839-48f134266015 (date of access – 28.10.2024) (In Russ.)).


12. Мкртумян А.М. Сравнительный анализ эффективности препаратов для лечения ранних нарушений углеводного обмена (предиабета). Терапевтический архив. 2024; 96(4): 419–428. (Mkrtumyan A.M. Comparative analysis of the drugs efficacy for carbohydrate metabolism early disorders (prediabetes) treatment: A review. Terapevticheskiy arkhiv = Therapeutic Archive. 2024; 96(4): 419–428 (In Russ.)).


https://doi.org/10.26442/00403660.2024.04.202709. EDN: LPKFZV.


About the Autors

Andrey G. Malyavin, MD, Dr. Sci. (Medicine), professor, general secretary of Russian Scientific Medical Society of Internal Medicine (RSMSIM), professor of the Department of phthisiology and pulmonology of N.A. Semashko Scientific and Educational Institute of Clinical Medicine of Russian University of Medicine of the Ministry of Healthcare of Russia, chief external expert – pulmonologist of the Ministry of Healthcare of Russia for the Central Federal District. Address: 107150, Moscow, 39/2 Losinoostrovskaya St.
E-mail: maliavin@mail.ru
ORCID: https://orcid.org/0000-0002-6128-5914
Ashot M. Mkrtumyan, MD, Dr. Sci. (Medicine), professor, head of the Department of endocrinology of N.A. Semashko Scientific and Educational Institute of Clinical Medicine of Russian University of Medicine of the Ministry of Healthcare of Russia, head of the Scientific Department of endocrine and metabolic disorders of A.S. Loginov Moscow Clinical Research Center of the Department of Healthcare of Moscow, Honored Doctor of Russia. Address: 127006, Moscow, 4 Dolgorukovskaya St.
E-mail: vagrashot@mail.ru
ORCID: https://orcid.org/0000-0003-1316-5245
Tatyana V. Adasheva, MD, Dr. Sci. (Medicine), professor, member of the presidium of RSMSIM, professor of the Department of therapy and preventive medicine of N.A. Semashko Scientific and Educational Institute of Clinical Medicine of Russian University of Medicine of the Ministry of Healthcare of Russia. Address: 107150, Moscow, 39/2 Losinoostrovskaya St.
E-mail: adashtv@mail.ru
ORCID: https://orcid.org/0000-0002-3763-8994
Laura Z. Bolieva, MD, Dr. Sci. (Medicine), professor, member of the presidium of RSMSIM, head of the Department of pharmacology with clinical pharmacology of North Ossetian State Medical Academy of the Ministry of Healthcare of Russia, Honored Doctor of North Ossetia-Alania Republic, chief external expert – pulmonologist, allergologist-immunologist of the Ministry of Healthcare of North Ossetia – Alania Republic. Address: 362019, Vladikavkaz, 40 Pushkinskaya St.
E-mail: bolievalz@mail.ru
ORCID: https://orcid.org/0000-0002-1820-7726


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