Русский
The effect of aerobic exercise on the development of iron deficiency in young women
DOI: https://dx.doi.org/10.18565/therapy.2023.1.48-54
Kovalev A.V., Tishko V.V., Polyakov A.S., Gornostaev D.A., Zhivopisceva A.M., Bologov S.G., Tyrenko V.V.
S.M. Kirov Military Medical Academy of the Ministry of Defenсe of the Russian Federation, Saint Petersburg
The purpose of the study: to assess the effect of physical exertion on the formation of iron deficiency conditions in young female athletes.
Material and methods. 68 young female athletes who participated in sports camps included in the study. During the study, the subjects were examined for a complete blood count and serum ferritin before the start of the training camp (the 1st point) and on the day 30 (the 2nd point). Then the study participants were divided into 3 groups: «healthy» women, with LID and with iron deficiency anemia (IDA). The group with IDA was excluded from the study. The group with LID was divided into two: LID + therapy with iron 200 mg per day and a follow-up group without therapy. An intergroup comparative analysis of the prevalence of iron deficiency conditions at the 1st point of the study and an intragroup comparative analysis of the data obtained between the 1st and 2nd points of the study were carried out.
Results. At the 1st point of the study, 36,7% of women were diagnosed with LID, 23,5% with IDA. By the second point of the study in the group of «healthy» women, 48% had LID debuted, 9% had IDA; in the group of LID without therapy, 42% had IDA debuted; in the LID group with iron therapy, 100% had a physiological reaction in the form of an increase in hemoglobin levels against the background of an increase in ferritin.
Conclusion. Data on the high incidence of LID and IDA in young female athletes have been obtained. Physical activity during sports training camps demonstrated a statistically significant effect on ferrokinetics and the formation of iron deficiency states after 30 days of exposure. The effectiveness of preventive administration of therapeutic dosage of iron therapy in order to prevent the development of iron deficiency anemia during intense physical exertion has been proven.
Literature
1. World Health Organization. WHO Global Anaemia estimates, 2021 Edition. URL: https://www.who.int/data/gho/data/themes/topics/anaemia_in_women_and_children (date of access – 01.01.2023). 2. Milman N., Taylor C.L., Merkel J., Brannon P.M. Iron status in pregnant women and women of reproductive age in Europe. Am J Clin Nutr. 2017; 106(Suppl 6): 1655S–62S. https://dx.doi.org/10.3945/ajcn.117.156000. 3. Здравоохранение в России. 2019. Статистический сборник. Росстат. М. 2019; 170 с. [Healthcare in Russia, 2019. Statistical compendium. Federal State Statistics Service. Moscow. 2019; 170 pp. (In Russ.)]. ISBN: 978-5-89476-470-2. 4. Росстат. Распределение населения по возрастным группам. 2020. Доступ: https://rosstat.gov.ru/folder/12781 (дата обращения – 01.01.2023). [Distribution of the population by age groups. 2020. Federal State Statistics Service.URL: https://rosstat.gov.ru/folder/12781 (date of access – 01.01.2023) (In Russ.)]. 5. Lane D.J.R., Merlot A.M., Huang M.L.H. et al. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochim Biophys Acta. 2015; 1853(5): 1130–44. https://dx.doi.org/10.1016/j.bbamcr.2015.01.021. 6. Сахин В.Т., Крюков Е.В., Рукавицын О.А. Анемия хронических заболеваний – особенности патогенеза и попытка классификации. Тихоокеанский медицинский журнал. 2019; (1): 33–37. [Sahin V.T, Kryukov E.V, Rukavicyn O.A. Anemia of chronic diseases – Features of pathogenesis and an attempt at classification. Tikhookeanskiy meditsinskiy zhurnal = Pacific Medical Journal. 2019; (1): 33–37 (In Russ.)]. https://dx.doi.org/10.17816/rmmar81177. EDN: VZVQYY. 7. Brune M., Magnusson B., Persson H., Hallberg L. Iron losses in sweat. Am J Clin Nutr. 1986; 43(3): 438–43.https://dx.doi.org/10.1093/ajcn/43.3.438. 8. Green R., Charlton R., Seftel H. et al. Body iron excretion in man. A collaborative study. Am J Med. 1968; 45(3): 336–53.https://dx.doi.org/10.1016/0002-9343(68)90069-7. 9. Богданов А.Н., Волошин С.В., Тыренко В.В. с соавт. Железодефицитная анемия у пациентов пожилого и старческого возраста. Успехи геронтологии. 2020; 33(6): 1150–1157. [Bogdanov A.N., Voloshin S.V., Tyrenko V.V., Polyakov A.S. Iron deficiency anemia in elderly and senile patients. Uspekhi gerontologii = Advances in Gerontology. 2020; 33(6): 1150–1157 (In Russ.)].https://dx.doi.org/10.34922/AE.2020.33.6.018. EDN: AXAQGQ. 10. Koca E., Cetiner D.A., Buyukasik Y. et al. Bone marrow iron staining is a reliable test for elimination of iron deficiency anemia rather than its diagnosis. UHOD – Uluslararasi Hematol Derg. 2013; 23(4): 260–63. https://dx.doi.org/10.4999/uhod.13011. 11. Guyatt G.H., Oxman A.D., Ali M. et al. Laboratory diagnosis of iron-deficiency anemia – An overview. J Gen Intern Med. 1992; 7(2): 145–53. https://dx.doi.org/10.1007/BF02598003. 12. Pal S., Rishi P., Pawaria S. et al. Prevalence of Iron deficiency with or without anemia in female athletes – A review. Eur J Mol Clin Med. 2020; 7(11): 2586–95. 13. Hershko C., Lahad A., Kereth D. Gastropathic sideropenia. Best Pract Res Clin Haematol. 2005; 18(2): 363–80.https://dx.doi.org/10.1016/j.beha.2004.10.002. 14. Young I., Parker H.M., Rangan A. et al. Association between haem and non-haem iron intake and serum Ferritin in healthy young women. Nutrients. 2018; 10(1): 1–13. https://dx.doi.org/10.3390/nu10010081. 15. Egan S.K., Tao S.S.H., Pennington J.A.T., Bolger P.M. US food and drug administration’s total diet study: Intake of nutritional and toxic elements, 1991–96. Food Addit Contam. 2002; 19(2): 103–25. https://dx.doi.org/10.1080/02652030110071354. 16. Hurrell R., Egli I. Iron bioavailability and dietary values. Am J Clin Nutr. 2010; 91 (5): 1461–67.https://dx.doi.org/10.3945/ajcn.2010.28674F. 17. Hallberg L., Rossander-Hulten L. Iron requirements. Am J Clin Nutr. 1991; 54(6): 1047–58. https://dx.doi.org/10.1007/BF02786235. 18. Trumbo P., Yates A.A., Schlicker S., Poos M. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron. J Am Diet Assoc. 2001; 101(3): 294–301. https://dx.doi.org/10.1016/S0002-8223(01)00078-5. 19. Munro M.G., Critchley H.O.D., Fraser I.S. et al. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynecol Obstet. 2018; 143(3): 393–408. https://dx.doi.org/10.1002/ijgo.12666. 20. Pedlar C.R., Brugnara C., Bruinvels G., Burden R. Iron balance and iron supplementation for the female athlete: A practical approach. Eur J Sport Sci. 2018; 18(2): 295–305. https://dx.doi.org/10.1080/17461391.2017.1416178. 21. McClung J.P., Karl J.P., Cable S.J. et al. Randomized, double-blind, placebo-controlled trial of iron supplementation in female soldiers during military training: Effects on iron status, physical performance, and mood. Am J Clin Nutr. 2009; 90(1): 124–31.https://dx.doi.org/10.3945/ajcn.2009.27774. 22. Beard J., Tobin B. Iron status and exercise. Am J Clin Nutr. 2000; 72(2 Suppl): 594S–97S. https://dx.doi.org/10.1093/ajcn/72.2.594S. 23. Badenhorst C.E., Goto K., Brien W.J.O. et al. Iron status in athletic females, a shift in perspective on an old paradigm Iron status in athletic females, a shift in perspective on an old paradigm. J Sports Sci. 2021; 39(14): 1565–75.https://dx.doi.org/10.1080/02640414.2021.1885782. 24. Habte K., Adish A., Zerfu D. et al. Iron, folate and vitamin B12 status of Ethiopian professional runners. Nutr Metab (Lond). 2015; 12: 62. https://dx.doi.org/10.1186/s12986-015-0056-8.
About the Autors
Alexey V. Kovalev, external competitor at the Department of faculty therapy, ФГБВОУ ВО S.M. Kirov Military Medical Academy of the Ministry of Defence of the Russian Federation. Address: 194044, Saint Petersburg, 6A Akademika Lebedeva Str. E-mail: Kovalev.mmeda@yandex.ru. ORCID: https://orcid.org/0000-0001-5884-2057
Valery V. Tishko, MD, associate professor, deputy head of the Department of faculty therapy, S.M. Kirov Military Medical Academy of the Ministry of Defence of the Russian Federation. Address: 194044, Saint Petersburg, 6A Akademika Lebedeva Str. E-mail: vtishko@gmail.com. ORCID: https://orcid.org/0000-0003-4696-3569
Alexey S. Polyakov, PhD in Medical Sciences, head of the Department of hematology of the Department of faculty therapy, S.M. Kirov Military Medical Academy of the Ministry of Defence of the Russian Federation. Address: 194044, Saint Petersburg, 6A Akademika Lebedeva Str. E-mail: doctorpolyakov@gmail.com. ORCID: https://orcid.org/0000-0001-9238-8476
Dmitry A. Gornostaev, head of the Department of intensive chemotherapy and myelotransplantation of the Department of faculty therapy, S.M. Kirov Military Medical Academy of the Ministry of Defence of the Russian Federation. Address: 194044, Saint Petersburg, 6A Akademika Lebedeva Str. E-mail: gorniispb@gmail.com
Aliya M. Zhivopistseva, PhD in Medical Sciences, senior lecturer at the Department of faculty therapy, S.M. Kirov Military Medical Academy of the Ministry of Defence of the Russian Federation. Address: 194044, Saint Petersburg, 6A Akademika Lebedeva Str. E-mail: aliamir@list.ru. ORCID: https://orcid.org/0000-0002-1360-1652
Sergei G. Bologov, MD, professor, professor of the Department of faculty therapy, S.M. Kirov Military Medical Academy of the Ministry of Defence of the Russian Federation. Address: 194044, Saint Petersburg, 6A Akademika Lebedeva Str. E-mail: bologovs@inbox.ru
Vadim V. Tyrenko, MD, professor, head of the Department of faculty therapy, S.M. Kirov Military Medical Academy of the Ministry of Defence of the Russian Federation. Address: 194044, Saint Petersburg, 6A Akademika Lebedeva Str. E-mail: vadim_tyrenko@mail.ru. ORCID: https://orcid.org/0000-0002-0470-1109
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