Русский
The effect of increased hepcidin expression on the pharmacokinetics of ferrous sulfate in patients with iron deficiency on the background of anemia of chronic diseases
DOI: https://dx.doi.org/10.18565/therapy.2022.4.56-61
Osipyan Е.Ae., Makhova A.A., Drozdov V.N., Shikh E.V.
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
The aim is to study the pharmacokinetics of iron preparations in patients with ID which arised on the background of anemia of chronic diseases (ACD), comparatively with patients with isolated iron deficiency anemia (IIDA).
Material and methods. A comparison of pharmacokinetics of iron sulfate in 15 female patients with IIDA and 15 female patients with ID are on the background of ACD was made.
Results. The main indicators of iron exchange in the study groups were not significantly different, except for the level of iron-regulating protein hepcidin in patients with ACD + ID comparatively to IIDA patients, 6,1±3,6 versus 15,1±7,3 ng/ml. The area under the curve (AUC) of basal level of iron was 150,96±43,97 μmol×hour/l in patients with IIDA and 112,65±15,88 μmol×hour/l in patients with ACD + ID. After taking 200 mg of iron sulfate AUC increased to 310,18±73,02 μmol×hour/l in patients with IIDA and up to 141,4 μmol×hour/l in patients with ACD + ID. In patients with IIDA, the value of the maximum concentration (Cmax) of iron sulfate in blood (21,2 μmol/l) was achieved more quickly – after 3,1 hours after medicine intake; in patients with ACD and ID Cmax (5,2 μmol/l) was achieved only after 5,6 hours.
Conclusion. The obtained data indicate the effect of increased influence of hepcidin at pharmacokinetics of iron preparations in patients with ACD, accompanied by ID.
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About the Autors
Elena Ae. Osipyan, postgraduate student of the Department of clinical pharmacology and propaedeutics of internal diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Siechenov University). Address: 119991, Moscow, 8/2 Trubetskaya Str. E-mail: lenaosipyan@gmail.com.
ORCID: https://orcid.org/0000-0003-2134-0197
Anna A. Makhova, Dr. med. habil., associate professor, associate professor of the Department of clinical pharmacology and propaedeutics of internal diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Siechenov University). Address: 119991, Moscow, 8/2 Trubetskaya Str.
ORCID: https://orcid.org/0000-0001-9817-9886
Vladimir N. Drozdov, Dr. med. habil., professor, professor of the Department of clinical pharmacology and propaedeutics of internal diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Siechenov University). Address: 119991, Moscow, 8/2 Trubetskaya Str. ORCID: https://orcid.org/0000-0002-0535-2916
Evgenia V. Shikh, Dr. med. habil., professor, head of the Department of clinical pharmacology and propaedeutics of internal diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya Str. ORCID: https://orcid.org/0000-0001-6589-7654
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