Therapy » Lipid-lowering therapy today and tomorrow

Lipid-lowering therapy today and tomorrow

DOI: https://dx.doi.org/10.18565/therapy.2023.4.77-87

Boeva O.I., Kokorin V.A., Latiy V.V.
1) Central State Medical Academy of the executive office of the President of the Russian Federation, Moscow; 2) N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation, Moscow; 3) Polyclinic №1 of the executive office of the President of the Russian Federation, Moscow

Abstract. Reducing the relative risk of cardiovascular events is proportional to the absolute reduction of low-density lipoprotein cholesterol (LDL cholesterol), which is the main goal of therapy, regardless of the method of reduction. During the past decades, therapeutic algorithms of hypercholesterolemia correction have been improved, providing clinical benefits in terms of cardiovascular outcomes. Current review is dedicated to currently available lipid-lowering drugs: statins, ezetimibe, PCSK9 inhibitors (monoclonal antibodies, small interfering RNA preparation) and bempedoic acid. Recent changes in lipid-lowering regimens are also discussed, including the early use of lipid-lowering drug combinations to achieve relatively low LDL-C targets in patients at high/very high CV risk.

Keywords: bempedoic acid, PCSK9 inhibitors, hypercholesterolemia, ezetimibe, cardiovascular risk, statins, atherosclerosis

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About the Autors

Olga I. Boeva, MD, associate professor, professor of the Department of therapy, cardiology and functional diagnostics with the course of nephrology, Central State Medical Academy of the Administration of the President of the Russian Federation, general practitioner of Polyclinic No.1 of the Administration of the President of the Russian Federation. Address: 119002, Moscow, 26/28, building 1 Sivtsev Vrazhek Lane. E-mail: box0271@mail.ru.
ORCID: https://orcid.org/0000-0002-1816-8309
Valentin A. Kokorin, MD, associate professor, professor of the Department of hospital therapy named after academician P.E. Lukomsky of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 111539, Moscow, 23 Veshnyakovskaya Str. E-mail: valentinkokorin@yahoo.com. ORCID: https://orcid.org/0000-0001-8614-6542
Vladimir V. Latiy, general practitioner of Polyclinic No.1 of the Administration of the President of the Russian Federation. Address: 119002, Moscow, 26/28, bldg 1 Sivtsev Vrazhek Lane. E-mail: vv_00@list.ru.
ORCID: https://orcid.org/0000-0002-5317-0543

Lipid-lowering therapy today and tomorrow

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