Липидснижающая терапия сегодня и завтра


DOI: https://dx.doi.org/10.18565/therapy.2023.4.77-87

О.И. Боева, В.А. Кокорин, В.В. Латий

1) ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента РФ, г. Москва; 2) ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, г. Москва; 3) ФГБУ «Поликлиника № 1» Управления делами Президента РФ, г. Москва
Аннотация. Снижение относительного риска сердечно-сосудистых событий пропорционально абсолютному снижению уровня холестерина липопротеидов низкой плотности (ХС ЛНП), являющегося основной целью терапии, независимо от способа снижения. За последние десятилетия терапевтические алгоритмы коррекции гиперхолестеринемии были усовершенствованы, что обес­печило клинические преимущества в отношении сердечно-сосудистых исходов. Предлагаемый обзор посвящен доступным в настоящее время препаратам для снижения уровня липидов: статинам, эзетимибу, ингибиторам PCSK9 (моноклональным антителам, препарату малой интерферирующей РНК) и бемпедоевой кислоте. Также обсуждаются последние изменения в режимах липидснижающей терапии, включая раннее применение комбинаций гиполипидемических препаратов для достижения относительно низкого целевого уровня ХС ЛНП у пациентов высокого/очень высокого сердечно-сосудистого риска.

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Об авторах / Для корреспонденции


Ольга Игоревна Боева, д.м.н., доцент, профессор кафедры терапии, кардиологии и функциональной диагностики с курсом нефрологии ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента РФ, врач-терапевт ФГБУ «Поликлиника № 1» Управления делами Президента РФ. Адрес: 119002, г. Москва, пер. Сивцев Вражек, д. 26/28, к. 1. E-mail: box0271@mail.ru.
ORCID: https://orcid.org/0000-0002-1816-8309
Валентин Александрович Кокорин, д.м.н., доцент, профессор кафедры госпитальной терапии им. академика П.Е. Лукомского лечебного факультета ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России. Адрес: 111539, г. Москва, Вешняковская ул., д. 23. E-mail: valentinkokorin@yahoo.com. ORCID: https://orcid.org/0000-0001-8614-6542
Владимир Владимирович Латий, врач-терапевт ФГБУ «Поликлиника № 1» Управления делами Президента РФ. Адрес: 119002, г. Москва, пер. Сивцев Вражек, д. 26/28, к. 1. E-mail: vv_00@list.ru.
ORCID: https://orcid.org/0000-0002-5317-0543


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