Perspectives for the use of nanotechnologies in Helicobacter pylori eradication


DOI: https://dx.doi.org/10.18565/therapy.2023.7.168-175

Bakulina N.V., Savilova I.V., Lutaenko E.A., Tsurtsumia D.B.

I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia, Saint Petersburg
Abstract. Current H. pylori eradication regimens mainly are consisting of a combination of two antibacterial agents, bismuth drug, and a proton pump inhibitor. Despite enhanced therapy, the frequency of effective eradication is steadily declining due to the growth of H. pylori antibiotic resistance. In this regard, it seems promising to develop anti-Helicobacter medicines with improved pharmacokinetic parameters. In this regard, nanocarriers have unique advantages: they increase the bioavailability of medicines, reduce degradation of antibiotics in the acidic environment of the stomach, and provide targeted delivery of active substances to the target. In addition, nanopreparations contribute to the destruction of H. pylori biofilms. The review article presents the results of studies on the use of lipid-based nanoparticles, polymeric nanoparticles and inorganic nanoparticles to optimize the treatment of H. pylori-associated diseases.

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About the Autors


Natalya V. Bakulina, MD, professor, head of the Department of internal medicine, clinical pharmacology and nephrology, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 195067, Saint Petersburg, 47 Piskarevsky Avenue.
E-mail: nv_bakulina@mail.ru
ORCID: https://orcid.org/0000-0003-4075-4096
Inna V. Savilova, PhD in Medical Sciences, assistant at the Department of internal medicine, clinical pharmacology and nephrology, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 195067, Saint Petersburg, 47 Piskarevsky Avenue.
E-mail: inna.savilova@gmail.com
ORCID: https://orcid.org/0000-0001-6463-6663
Elena A. Lutaenko, PhD in Medical Sciences, associate professor of the Department of internal medicine, clinical pharmacology and nephrology, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 195067, Saint Petersburg, 47 Piskarevsky Avenue.
E-mail: e-lutaenko@yandex.ru
ORCID: https://orcid.org/0000-0003-3472-3728
Daredzhan B. Tsurtsumiya, PhD in Medical Sciences, associate professor of the Department of internal medicine, clinical pharmacology and nephrology, I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia. Address: 195067, Saint Petersburg, 47 Piskarevsky Avenue.
E-mail: D.Tcurtcumiya@szgmu.ru
ORCID: https://orcid.org/0000-0001-7806-9364


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