Therapy » Estimation of the efficacy of probiotic cocktails in correcting intestinal microbial-tissue barrier and subjective well-being of convalescents who have survived mild forms of COVID-19

Estimation of the efficacy of probiotic cocktails in correcting intestinal microbial-tissue barrier and subjective well-being of convalescents who have survived mild forms of COVID-19

DOI: https://dx.doi.org/10.18565/therapy.2024.7.35-42

Gurovskikh A.V., Grigorovich M.S.
Kirov State Medical University of the Ministry of Healthcare of Russia

Abstract. Probiotic cocktails are a complex of pro-, meta- and prebiotics in a liquid nutrient solution, which can play role of a substrate for maintaining the metabolic activity of normobiota.
The aim: to estimate the dynamics of a number of somatopsychic status indexes and parameters of intestinal microbial-tissue barrier in convalescents with mild forms of COVID-19 taking a course of functional products in the form of biococktails.
Material and methods. Open observational study was performed in 2021–2023. 150 individuals aged 20–55 years with mild forms of COVID-19 were observed. The main group received a course of biococktails for 28 ± 2 days. Parameters of subjective well-being and asthenia manifestations were studied using the Giessen questionnaire of psychosomatic complaints, FSS asthenia severity assessment scales and MFI- 20 subjective asthenia assessment. Laboratory stage of the research included a study of the level and spectrum of short-chain fatty acids (SCFA) in stool. Permeability of the intestinal epithelial barrier was estimated by studying the dynamics of the alpha-1-antitrypsin (AAT) level in stool.
Results. In the main group, a significant decrease in the parameters of somatopsychic manifestations on the scales of “rheumatic factor” (p = 0.000003), “exhaustion” and “stomach complaints” (p = 0.000024), “heart complaints” (p = 0.001124), “pressure complaints” (p = 0.0000001), the sum of points of all scales on the FSS questionnaire (p = 0.000019), as well as the values of the subscales “general asthenia” and “physical asthenia” (p = 0.002) on the MFI-20 took place. In the comparison group, there was no significant dynamics of similar indexes. The initial study of SCFA in stool showed that initially in both groups there was a decrease in the absolute content of all types of acids. The level of AAT in stool in the dynamics of the study was two times lower than the initial level (16.544 ± 1.047, 8.078 ± 3.944, p = 0.041).
Conclusion. A positive influence of biococktails at the dynamics of the parameters of somatopsychic status and microbiocenosis in COVID-19 convalescents was found, which contributed to the restoration of their subjective well-being and functional activity.

Keywords: somatopsychic status, microbial-tissue complex, alpha-1-antitrypsin, short-chain fatty acids

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About the Autors

Anastasia V. Gurovskikh, MD, postgraduate student of the Department of family medicine and outpatient therapy, Kirov State Medical University of the Ministry of Healthcare of Russia. Address: 610002, Kirov, 112 Karla Marksa St.
E-mail: trefna@bk.ru
ORCID: https://orcid.org/0009-0008-8659-5493
Marina S. Grigorovich, MD, Dr. Sci. (Medicine), associate professor, head of the Department of family medicine and outpatient therapy, Kirov State Medical University of the Ministry of Healthcare of Russia. Address: 610002, Kirov, 112 Karla Marksa St.
E-mail: grigorovich-mari@mail.ru
ORCID: https://orcid.org/0000-0002-2485-396X

Estimation of the efficacy of probiotic cocktails in correcting intestinal microbial-tissue barrier and subjective well-being of convalescents who have survived mild forms of COVID-19

Literature

About the Autors

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