Русский
Correlation between estrogen deficiency and non-alcoholic fatty liver disease in female patients
DOI: https://dx.doi.org/10.18565/therapy.2024.8.8-15
Dora S.V., Khalimov Yu.Sh., Mekhtiev S.N., Lisker A.V., Zimina M.V., Semikova G.V., Volkova A.R., Cherebillo I.V., Polyakova Yu.V.
Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia
The aim: to study the frequency and severity of liver steatosis in female patients with premature ovarian failure (POF).
Material and methods. The study included 86 non-obese female patients aged 29–40 years, who were divided into three groups: group 1 (control, n = 40) – females with a regular menstrual cycle (MC) and normal levels of follicle-stimulating hormone (FSH) and estradiol; group 2 (n = 29) – females who had not had menstruation for more than 3 months and had an increased FSH level; group 3 (n = 17) – females with premature menopause (PM). On days 3–5 of the menstrual cycle, blood sampling was taken and the following parameters were assessed: FSH, estradiol, glucose, insulin, triglycerides, low- and high-density lipoproteins, total cholesterol, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase. Waist circumference (WC) was measured, body mass index, HOMA-IR index, and liver steatosis coefficient FLI (Fatty Liver Index) were calculated, and an ultrasound examination (US) of liver was performed.
Results. As estrogen deficiency increased, the examined females showed a significant increase in WC (p = 0.001). Patients with estrogen deficiency had significantly worse carbohydrate metabolism and lipid profile. Liver function tests were significantly higher in the group of female patients with PM. FLI coefficient was 30.0 and 41.5 in patients of groups 2 and 3, respectively, versus 9.0 in group 1 (control). A negative correlation was found between the estradiol level and FLI coefficient (r = -0.524; p 0.001). FLI index became more sensitive than ultrasound data for assessing the degree of steatosis and NAFLD incidence.
Conclusion. PM negatively affects female’s metabolic health. Early diagnosis and prevention of NAFLD in female patients with POF will prevent irreversible liver changes and reduce the risk of cardiovascular complications.
Literature
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About the Autors
Svetlana V. Dora, MD, Dr. Sci. (Medicine), professor, professor of the Department of faculty therapy with the course of endocrinology, cardiology with clinic named after Academician G.F. Lang, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: doras2001@mail.ru
ORCID: https://orcid.org/0000-0002-8249-6075. eLibrary SPIN: 9845-0065
Yuri Sh. Khalimov, MD, Dr. Sci. (Medicine), professor, head of the Department of faculty therapy with the course of endocrinology, cardiology with clinic named after Academician G.F. Lang, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: yushkha@gmail.com
ORCID: https://orcid.org/0000-0002-7755-7275. eLibrary SPIN: 7315-6746
Sabir N. Mekhtiev, MD, Dr. Sci. (Medicine), professor, professor of the Department of hospital therapy with the course of allergology and immunology named after Academician Chernorutsky with the clinic, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: sabirm@mail.ru
ORCID: https://orcid.org/0000-0001-7367-9219
Anna V. Lisker, MD, PhD (Medicine), head of the Endocrinology Department, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: a.lisker@mail.ru
ORCID: https://orcid.org/0000-0003-4295-1202. eLibrary SPIN: 3688-1505
Margarita V. Zimina, MD, postgraduate student of the Department of faculty therapy with the course of endocrinology, cardiology with clinic named after Academician G.F. Lang, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: rita.zimina.1997@mail.ru
ORCID: https://orcid.org/0009-0006-5004-2825
Galina V. Semikova, MD, PhD (Medicine), assistant at the Department of faculty therapy with the course of endocrinology, cardiology with clinic named after Academician G.F. Lang, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: semikovagv@yandex.ru
ORCID: https://orcid.org/0000-0003-0791-4705
Anna R. Volkova, MD, Dr. Sci. (Medicine), professor of the Department of faculty therapy with the course of endocrinology, cardiology with clinic named after Academician G.F. Lang, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: volkovaa@mail.ru
ORCID: https://orcid.org/0000-0002-5189-9365. eLibrary SPIN: 4007-1288
Irina V. Cherebillo, MD, clinical resident with a specialization in “Endocrinology” of the Department of faculty therapy with the course of endocrinology, cardiology with clinic named after Academician G.F. Lang, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: icherebillo@yandex.ru
ORCID: https://orcid.org/0009-0000-7067-296X
Yulia V. Polyakova, student of the Faculty of general medicine, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of Russia. Address: 197022, Saint Petersburg, 6/8 Lva Tolstogo St.
E-mail: cumparsita01@gmail.com
ORCID: https://orcid.org/0009-0008-0013-9615
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