Arrhythmic syndrome of undifferentiated connective tissue dysplasia


DOI: https://dx.doi.org/10.18565/therapy.2023.9.150-156

Loginova E.N., Nechaeva G.I., Dakuko A.N., Bogatyrev I.V., Potapov V.V., Kirichenko N.A.

1) Omsk State Medical University of the Ministry of Healthcare of Russia; 2) Clinical Diagnostic Center, Omsk
Abstract. Cardiac rhythm and conduction disturbances are widespread among patients with hereditary and undifferentiated connective tissue dysplasia. Arrhythmias are the leading cause of serious cardiovascular outcomes in this group of patients. The presented clinical case demonstrates the clinical features and diagnosis of arrhythmic syndrome in a patient with undifferentiated connective tissue dysplasia (UCTD). Phenotypic features of UCTD (asthenic constitution, scoliosis, underweight, joint hypermobility and others) indicated a high diagnostic coefficient of this pathology (more than 23 points) and a possible risk of an unfavorable prognosis. An increase level of the NTproBNP, high-grade ventricular extra systoles and initial signs of longitudinal strain in a young patient (without CHF) may indicate a high cardiovascular risk in patients with phenotypic features of UCTD.

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About the Autors


Ekaterina N. Loginova, PhD in Medical Sciences, associate professor, associate professor of the Department of internal medicine and family medicine with course of additional professional education, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: ekaterina.n.loginova@yandex.ru
ORCID: https://orcid.org/0000-0002-0601-7044
Galina I. Nechaeva, MD, professor, professor of the Department of internal medicine and family medicine with course of additional professional education, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: profnechaeva@yandex.ru
ORCID https://orcid.org/0000-0002-2255-128X
Anastasia N. Dakuko, PhD in Medical Sciences, associate professor of the Department of hospital pediatrics with a course of additional professional education, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: doc-man85@mail.ru
ORCID https://orcid.org/0000-0001-8390-343X
Ilya V. Bogatyrev, student of the 515th group of the Faculty of general medicine, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: ilyabogatyrev23339@icloud.com
ORCID: https://orcid.org/0000-0003-4016-2023
Victor V. Potapov, PhD in Medical Sciences, associate professor, associate professor of the Department of internal medicine and family medicine with course of additional professional education, Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: potapovvv@mail.ru
ORCID: https://orcid.org/0000–0002–3823–7367
Nikolai A. Kirichenko, junior researcher at Central Scientific Research Laboratory of Omsk State Medical University of the Ministry of Healthcare of Russia. Address: 644099, Omsk, 12 Lenina St.
E-mail: honomer_1608@mail.ru
ORCID: https://orcid.org/0000-0002-8411-0973


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