Assessment of vitamin d in women of reproductive age with connective tissue dysplasia


DOI: https://dx.doi.org/10.18565/therapy.2019.7.81-83

Smetanin M.Yu., Pimenov L.T., Chernyshova T.E., Kononova N.Yu.

1) Republican clinical and diagnostics Center of the Ministry of Healthcare of the Udmurt Republic, Izhevsk; 2) Izhevsk State medical Academy of the Ministry of Healthcare of Russia; 3) Health resort «Metallurg» JSC, Izhevsk
Connective tissue dysplasia (CTD) is considered as an important medical and social problem due to the wide prevalence among the population, particularly in women of childbearing and working age, increasing health care costs for treatment of this disease, but also high ranking among the causes of primary disability. The latter is particularly relevant not only in medical but also in social terms [1, 2].
Vitamin D supplementation – in terms of the metabolite 25(OH) D (calcidiol) – in women with undifferentiated connective tissue dysplasia (uCTD) is currently receiving special attention. It was established that patients with uCTD are at risk for obstetric and perinatal pathology, since the prevalence of this syndrome in women of reproductive age reaches 80%. UCTD can have adverse effects on pregnancy and childbirth, perinatal morbidity and mortality of newborns. In the available literature, there are isolated studies examining the status of vitamin D in women of reproductive age with uCTD. It should be noted that studies to assess vitamin D have been conducted mainly in children and adolescents. At the same time, this problem remains almost unexplored in women of reproductive age.
Keywords: vitamin D lack and deficiency, women of childbearing age, undifferentiated connective tissue dysplasia, vitamin D, calcitriol
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About the Autors

Mikhail Yu. Smetanin, PhD, doctor of ultrasound diagnostics of Republican Clinical Diagnostic Center of the Ministry of Healthcare of the Udmurt Republic. Address: 426009, Izhevsk, 87B Lenina Str. Tel.: +7 (3412) 37-49-58; 8 (912) 856-03-33. E-mail: Migele1977@rambler.ru. ORCID 0000-0002-7943-8982
Leonid T. Pimenov, MD, professor, head of the Department of general practitioner and internal medicine with the course of emergency medical care of advanced training faculty of Izhevsk State medical Academy of the Ministry of Healthcare of Russia. Address: 426034, Izhevsk, 281 Kommunarov Str. Tel: +7 (3412) 52-53-09; 8 (3412) 91-82-79. ORCID 0000-0003-3785-5603
Tatyana E. Chernyshova, MD, professor of the Department of general practitioner and internal medicine with the course of emergency medical care of advanced training faculty of Izhevsk State medical Academy of the Ministry of Healthcare of Russia. Address: 426034, Izhevsk, 281 Kommunarov Str. Tel.: +7 (3412) 52-53-09; 8 (3412) 91-82-79. ORCID 0000-0001-5176-5730
Natalya Yu. Kononova, PhD, General director and Chief physician of «Metallurg» sanatorium. Address: 426009, Izhevsk, 2 Kurortnaya Str. Tel.: +7 (3412) 68-24-54; 8 (905) 877-78-24. E-mail: conon.nata@yandex.ru. ORCID 0000-0002-9253-2113


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