Possibilities of local therapy by fixed pharmaceutical combinations in managing patients with acute tonsillopharyngitis


DOI: https://dx.doi.org/10.18565/therapy.2024.10.152-162

Svistushkin V.M., Nikiforova G.N., Toldanov A.V., Shustrova A.N., Kulikova E.D., Sinkov E.V., Zolotova A.V., Shevchik E.A.

1) I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University); 2) Scientific and Technological Center of Unique Instrument Engineering of the Russian Academy of Sciences, Moscow
Abstract. One of the most common symptoms of upper respiratory tract diseases is a sore throat pain caused by the development of acute tonsillopharyngitis (ATP) of various etiologies. Most often, this condition is caused by viruses, not bacterial agents. Currently, much attention is paid to the development of alternative methods for treating ATP to reduce the frequency of irrational antibiotic therapy. Topical drugs with etiological, pathogenetic and symptomatic mechanisms of action, i.e. local drugs with antimicrobial, antiseptic, anti-inflammatory and analgesic properties, are also of great importance. According to the results of the study presented in this article, use of Lysobact COMPLETE® spray allows effectively and safely achieve a significant therapeutic effect in patients with ATP, which is confirmed, among other things, by objective indexes.
Keywords: acute tonsillopharyngitis, tonsils, rational antibiotic therapy, tonsillitis, sore throat, lysozyme
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About the Autors

Valery M. Svistushkin, MD, Dr. Sci. (Medicine), professor, head of the Department of ear, nose and throat diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya St.
E-mail: svvm3@yandex.ru
ORCID: https://orcid.org/0000-0001-7414-1293
Galina N. Nikiforova, MD, Dr. Sci. (Medicine), professor, of the Department of ear, nose and throat diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya St.
E-mail: gn_nik_63@mail.ru
ORCID: https://orcid.org/0000-0002-8617-0179
Alexey V. Toldanov, MD, otolaryngologist, head of the surgery block of the Clinic of ear, throat and nose diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya St.
E-mail: toldanov@bk.ru
ORCID: https://orcid.org/0000-0002-6164-8594
Anna N. Shustrova, clinical resident of the Department of ear, nose and throat diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya St.
E-mail: james.ann@mail.ru
ORCID: https://orcid.org/0000-0001-8850-004X
Evgenia D. Kulikova, research engineer of Scientific and Technological Center of Unique Instrument Engineering of the Russian Academy of Sciences. Address: 117342, Moscow, 15 Butlerova St.
E-mail: jkul2001@gmail.com
ORCID: https://orcid.org/0009-0005-0595-4422
Eduard V. Sinkov, MD, PhD (Medicine), associate professor of the Department of ear, nose and throat diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya St.
E-mail: sinkov_e_v@staff.sechenov.ru
ORCID: https://orcid.org/0000-0003-4870-5977
Anna V. Zolotova, MD, PhD (Medicine), associate professor of the Department of ear, nose and throat diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya St.
E-mail: zolotova_a_v@staff.sechenov.ru
ORCID: https://orcid.org/0000-0002-3700-7367
Elena A. Shevchik, MD, PhD (Medicine), associate professor of the Department of ear, nose and throat diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya St.
E-mail: shevchik_e_a@staff.sechenov.ru
ORCID: https://orcid.org/0000-0002-0051-3792


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