Русский
Comorbid conditions in patients with psoriatic arthritis and hyperuricemia
DOI: https://dx.doi.org/10.18565/therapy.2025.1.74-80
Tsinzerling A.Yu., Mazurov V.I., Inamova O.V., Petrova M.S., Gaydukova I.Z.
1) I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia, Saint Petersburg; 2) V.A. Nasonova Clinical Rheumatology Hospital No. 25, Saint Petersburg
The aim: to study the incidence of comorbid diseases, their clinical course, characteristics, and efficacy of urate-lowering therapy (ULT) in case of PsA and HU combination.
Material and methods. Retrospective data of patients with PsA and HU (n = 130) and PsA without HU (n = 131) were studied. HU was considered as an increase in serum uric acid (UA) ≥ 360 μmol/L in the absence of gouty arthritis.
Results. PsA patients with and without HU were comparable in age, gender, disease activity, and immunogenetic characteristics. In the group of patients with PsA and HU, comparatively to PsA without HU, arterial hypertension (68.46 and 40.46%, respectively), hypercholesterolemia (53.08 and 27.48%), obesity (25.38 and 6.87%), prediabetes (21.54 and 12.21%), type 2 diabetes mellitus (DM 2) (29.23 and 12.21%), CKD (51.54 and 29.77%) were more common, in addition, the first group had a higher creatinine level (87.79 ± 19.26 and 77.86 ± 11.42 μmol/l); p < 0.05 for all parameters. Non-medicamentous ULT was effective in 30.36% of patients, medicamentous ULT – in 23.07%. These data can be explained by the fact that examined patients did not comply with the ULT dosing regimen and they stopped such therapy on their own. The efficacy of ULT did not depend on PsA activity: 81.25% of patients with moderate and 55.26% with high disease activity did not achieve the target UA level (p = 0.01).
Conclusion. HU leads to an increase in the incidence of hypertension, dyslipidemia, obesity, prediabetes, DM 2, and CKD in patients having PsA. The efficacy of non-medicamentous and medicamentous-based ULT in such patients is comparable in terms of target UA indicators achieving. It is advisable to continue studying the correlation between PsA activity and the efficacy of ULT.
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About the Autors
Alexandra Yu. Tsinzerling, MD, PhD (Medicine), rheumatologist at V.A. Nasonova Clinical Rheumatology Hospital No. 25, senior laboratory assistant at the Department of therapy, rheumatology, examination of temporary disability and quality of medical care with a course in hematology and transfusiology named after E.E. Eichwald of I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia. Address: 191015, Saint Petersburg, 41 Kirochnaya St.
E-mail: aleksa.fonturenko@mail.ru
ORCID: https://orcid.org/0000-0003-4860-0518. eLibrary SPIN: 5613-9035
Vadim I. Mazurov, MD, Dr. Sci. (Medicine), professor, academician of RAS, vice president of RSMSIM, principal scientific advisor and director of the Research Institute of Rheumatology, head of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care with a course in hematology and transfusiology named after E.E. Eichwald of I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia, head of Autoimmune center of V.A. Nasonova Clinical Rheumatology Hospital No. 25, chief freelance specialist – rheumatologist of the Healthcare Committee of the Government of Saint Petersburg, Honored Worker of Science of the Russian Federation. Address: 191015, Saint Petersburg, 41 Kirochnaya St.
E-mail: maz.nwgmu@yandex.ru
ORCID: https://orcid.org/0000-0002-0797-2051. Scopus Author ID: 16936315400. eLibrary SPIN: 6823-5482
Oksana V. Inamova, MD, PhD (Medicine), deputy director of the Research Institute of Rheumatology, assistant at the Department of therapy, rheumatology, examination of temporary disability and quality of medical care with a course in hematology and transfusiology named after E.E. Eichwald of I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia, chief physician of V.A. Nasonova Clinical Rheumatology Hospital No. 25. Address: 191015, Saint Petersburg, 41 Kirochnaya St.
E-mail: ovig74@mail.ru
ORCID: https://orcid.org/0000-0001-9126-3639. eLibrary SPIN: 8841-5496
Marianna S. Petrova, MD, PhD (Medicine), associate professor of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care with a course in hematology and transfusiology named after E.E. Eichwald of I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia, deputy chief physician of V.A. Nasonova Clinical Rheumatology Hospital No. 25. Address: 191015, Saint Petersburg, 41 Kirochnaya St.
E-mail: podagra@bk.ru
ORCID: https://orcid.org/0000-0001-5261-6614
Inna Z. Gaydukova, MD, Dr. Sci. (Medicine), deputy director of the Research Institute of Rheumatology, professor of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care with a course in hematology and transfusiology named after E.E. Eichwald of I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia, rheumatologist at V.A. Nasonova Clinical Rheumatology Hospital No. 25. Address: 191015, Saint Petersburg, 41 Kirochnaya St.
E-mail: ubp1976@list.ru
ORCID: https://orcid.org/0000-0003-3500-7256. Scopus Author ID: 55237525900. eLibrary SPIN: 3083-7996
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