Association of hyperuricemia with metabolism in patients with chronic kidney disease of 5th stage on hemodialysis


DOI: https://dx.doi.org/10.18565/therapy.2019.3.86-92

Prometnaya G.A., Batyushin M.M., Bondarenko N.B.

1) Regional Children`s clinical hospital, consultative polyclinic, Rostov-on-Don; 2) Rostov State medical University of the Ministry of healthcare of Russia
Hyperuricemia is significant factor of non-immune progression of chronic kidney disease (CKD), but the associated factors are little studied.
Purpose: to investigate association of hyperuricemia with indexes of metabolism in patients with CKD of 5th stage on hemodialysis.
Material and methods. It was made case compeer study, included of 102 patients with CKD of 5th stage on hemodialysis.
Results. Hyperuricemia registered in 71% (66 of 102) patients with malnutrition and in 76,9% (10) without it (p=0,468). Patients with hyperuricemia were younger on passport age (49,8±11,6 yrs. and 56,0±13,3 yrs.; p=0,025), and their metabolic age was significant higher than passport age (54,0 (42,0–62,5) and 49,8±11,6 yrs.; p=0,000). Quantity of postinfarction cardiosclerosis and chronic cardiac insufficiency more, than II stage and 3rd functional class was lower in hyperuricemia group than in non-hyperuricemia group – 9,2 (7) in compared with 26,9% (7; p=0,024) and 19,7 (15) in compared with 42,3% (11; p=0,021). Relative index of fat mass was higher in hyperuricemia than in non-hyperuricemia – 24,8±10,1 and 17,4±9,7% (p=0,002). All fluid volume in CKD of 5th stage was in reference corridor both in hyperuricemia and in non-hyperuricemia – 69,7 (53) and 65,4% (17; p=0,680). Quantity of intracellular fluid was lower than low reference limit in majority of patients: in hyperuricemia group – 64,5% (49), without it – 57,7% (15; p=0,537).
Conclusion. It was premature metabolic aging, lower quantity of postinfarction cardiosclerosis and chronic cardiac insufficiency more than II stage and 3rd functional class, more higher effectiveness of hemodialysis, supported normohydration in combination with intracellular dehydration in hyperuricemia, whereby hemodialysis was decreasing pro-inflammatory activity of hyperuricemia, as evidenced by C-reactive protein, fall within reference values.
Keywords: uric acid, hemodialysis, hyperuricemia, chronic kidney disease
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About the Autors

Galina A. Prometnaya, nephrologist of Regional Children`s clinical hospital consultative polyclinic. Address: 344085, Rostov-on-Don, 14 339th Rifle division Str. Tel.: +7 (863) 222-03-23. E-mail: prometnoy.d.v@gmail.com
Mikhail M. Batyushin, MD, professor of the Department of internal medicine No 2 of Rostov State medical University of the Ministry of Healthcare of Russia. Address: 344014, Rostov-on-Don, 29 Nakhichevansky Lane. Tel.: +7 (863) 201-44-23. E-mail: batjushin-m@rambler.ru
Nikolay B. Bondarenko, candidate of the Department of internal medicine No 2 of Rostov State medical University of the Ministry of Healthcare of Russia. Address: 344014, Rostov-on-Don, 29 Nakhichevansky Lane. Tel.: +7 (863) 201-44-23. E-mail: n.bondarenko61@gmail.com


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