Кардиологические осложнения при сепсисе


DOI: https://dx.doi.org/10.18565/therapy.2024.7.145-153

М.Г. Крупин, С.А. Близнюк, А.С. Жегалина, А.Г. Комарова, Е.П. Родионов, А.А. Плоскирева

1) ГБУЗ г. Москвы «Московский многопрофильный научно-клинический центр им. С.П. Боткина Департамента здравоохранения города Москвы»; 2) ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора, г. Москва
Аннотация. Несмотря на значительный прогресс в лечении, сепсис остается ведущей причиной летальности у пациентов в критическом состоянии. Среди основных органов-мишеней, поражаемых при сепсисе, особое место занимает сердце. На фоне тяжелого сепсиса и септического шока может развиваться сепсис-индуцированная кардиомиопатия, сопровождающаяся транзиторным нарушением сердечной функции и вносящая существенный вклад в исход заболевания. Другим распространенным осложнением со стороны сердца при сепсисе считается развитие нарушений ритма, которые проявляются возникновением предсердных и желудочковых аритмий. В статье рассмотрены распространенность, клинические проявления, подходы к лечению и профилактике основных кардиологических осложнений, наблюдаемых у больных с сепсисом.

Литература


1. Prest J., Sathananthan M., Jeganathan N. Current trends in sepsis-related mortality in the United States. Crit Care Med. 2021; 49(8): 1276–84.


https://doi.org/10.1097/ccm.0000000000005017. PMID: 34261926.


2. Meyer N., Harhay M.O., Small D.S. et al. Temporal trends in incidence, sepsis-related mortality, and hospital-based acute care after sepsis. Crit Care Med. 2018; 46(3): 354–60.


https://doi.org/10.1097/ccm.0000000000002872. PMID: 29474320. PMCID: PMC5896750.


3. Bauer M., Gerlach H., Vogelmann T. et al. Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019 – results from a systematic review and meta-analysis. Crit Care. 2020; 24(1): 239.


https://doi.org/10.1186/s13054-020-02950-2. PMID: 32430052. PMCID: PMC7236499.


4. Singer M., Deutschman C.S., Seymour C.W. et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016; 315(8): 801–10.


https://doi.org/10.1001/jama.2016.0287. PMID: 26903338. PMCID: PMC4968574.


5. Kakihana Y., Ito T., Nakahara M. et al. Sepsis-induced myocardial dysfunction: pathophysiology and management. J Intensive Care. 2016; 4: 22.


https://doi.org/10.1186/s40560-016-0148-1. PMID: 27011791. PMCID: PMC4804632.


6. Walker A.M.N., Drozd M., Hall M. et al. Prevalence and predictors of sepsis death in patients with chronic heart failure and reduced left ventricular ejection fraction. J Am Heart Assoc. 2018; 7(20): e009684.


https://doi.org/10.1161/jaha.118.009684. PMID: 30371261. PMCID: PMC6474963.


7. Hollenberg S.M., Singer M. Pathophysiology of sepsis-induced cardiomyopathy. Nat Rev Cardiol. 2021; 18(6): 424–34.


https://doi.org/10.1038/s41569-020-00492-2. PMID: 33473203.


8. Jentzer J.C., Lawler P.R., Van Houten H.K. et al. Cardiovascular events among survivors of sepsis hospitalization: A retrospective cohort analysis. J Am Heart Assoc. 2023; 12(3): e027813.


https://doi.org/10.1161/jaha.122.027813. PMID: 36722388. PMCID: PMC9973620.


9. Beesley S.J., Weber G., Sarge T. et al. Septic cardiomyopathy. Crit Care Med. 2018; 46(4): 625–34.


https://doi.org/10.1097/ccm.0000000000002851. PMID: 29227368.


10. Shahreyar M., Fahhoum R., Akinseye O. et al. Severe sepsis and cardiac arrhythmias. Ann Transl Med. 2018; 6(1): 6.


https://doi.org/10.21037/atm.2017.12.26. PMID: 29404352. PMCID: PMC5787725.


11. Jeong H.S., Lee T.H., Bang C.H. et al. Risk factors and outcomes of sepsis-induced myocardial dysfunction and stress-induced cardiomyopathy in sepsis or septic shock: A comparative retrospective study. Medicine (Baltimore). 2018; 97(13): e0263.


https://doi.org/10.1097/md.0000000000010263. PMID: 29595686. PMCID: PMC5895365.


12. Sato R., Kuriyama A., Takada T. et al. Prevalence and risk factors of sepsis-induced cardiomyopathy: A retrospective cohort study. Medicine. 2016; 95(39): e5031.


https://doi.org/10.1097/md.0000000000005031. PMID: 27684877. PMCID: PMC5265970.


13. Walkey A.J., Wiener R.S., Ghobrial J.M. et al. Incident stroke and mortality associated with new-onset atrial fibrillation in patients hospitalized with severe sepsis. JAMA. 2011; 306(20): 2248–54.


https://doi.org/10.1001/jama.2011.1615. PMID: 22081378. PMCID: PMC3408087.


14. Madjid M., Miller C.C., Zarubaev V.V. et al. Influenza epidemics and acute respiratory disease activity are associated with a surge in autopsy-confirmed coronary heart disease death: Results from 8 years of autopsies in 34,892 subjects. Eur Heart J. 2007; 28(10): 1205–10.


https://doi.org/10.1093/eurheartj/ehm035. PMID: 17440221. PMCID: PMC7108465.


15. Corrales-Medina V.F., Serpa J., Rueda A.M. et al. Acute bacterial pneumonia is associated with the occurrence of acute coronary syndromes. Medicine (Baltimore). 2009; 88(3): 154–59.


https://doi.org/10.1097/md.0b013e3181a692f0. PMID: 19440118.


16. Clayton T.C., Thompson M., Meade T.W. Recent respiratory infection and risk of cardiovascular disease: Case-control study through a general practice database. Eur Heart J. 2008; 29(1): 96–103.


https://doi.org/10.1093/eurheartj/ehm516. PMID: 18063596.


17. Ramirez J., Aliberti S., Mirsaeidi M. et al. Acute myocardial infarction in hospitalized patients with community-acquired pneumonia. Clin Infect Dis. 2008; 47(2): 182–87.


https://doi.org/10.1086/589246. PMID: 18533841.


18. Ciszewski A., Bilinska Z.T., Brydak L.B. et al. Influenza vaccination in secondary prevention from coronary ischaemic events in coronary artery disease: FLUCAD study. Eur Heart J. 2008; 29(11): 1350–58.


https://doi.org/10.1093/eurheartj/ehm581. PMID: 18187561.


19. Gurfinkel E.P., de la Fuente R.L., Mendiz O., Mautner B. Influenza vaccine pilot study in acute coronary syndromes and planned percutaneous coronary interventions: The FLU Vaccination Acute Coronary Syndromes (FLUVACS) Study. Circulation. 2002; 105(18): 2143–47.


https://doi.org/10.1161/01.cir.0000016182.85461.f4. PMID: 11994246.


20. Gurfinkel E.P., de la Fuente R.L. Two-year follow-up of the FLU Vaccination Acute Coronary Syndromes (FLUVACS) Registry. Tex Heart Inst J. 2004; 31(1): 28–32. PMID: 15061623. PMCID: PMC387429.


21. Ross R. Atherosclerosis – an inflammatory disease. N Engl J Med. 1999; 340(2): 115–26.


https://doi.org/10.1056/nejm199901143400207. PMID: 9887164.


22. Libby P. Inflammation in atherosclerosis. Nature. 2002; 420(6917): 868–74.


https://doi.org/10.1038/nature01323. PMID: 12490960.


23. Montarello N.J., Nguyen M.T., Wong D.T.L. et al. Inflammation in coronary atherosclerosis and its therapeutic implications. Cardiovasc Drugs Ther. 2022; 36(2): 347–62.


https://doi.org/10.1007/s10557-020-07106-6. PMID: 33170943.


24. Fuster V., Moreno P.R., Fayad Z.A. et al. Atherothrombosis and high-risk plaque: Part I: evolving concepts. J Am Coll Cardiol. 2005; 46(6): 937–54.


https://doi.org/10.1016/j.jacc.2005.03.074. PMID: 16168274.


25. Stary H.C., Chandler A.B., Dinsmore R.E. et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation. 1995; 92(5): 1355–74.


https://doi.org/10.1161/01.cir.92.5.1355. PMID: 7648691.


26. Hansson G.K., Robertson A.-K.L., Soderberg-Naucler C. Inflammation and atherosclerosis. Annu Rev Pathol. 2006; 1: 297–329.


https://doi.org/10.1146/annurev.pathol.1.110304.100100. PMID: 18039117.


27. Ambrose J.A., Tannenbaum M.A., Alexopoulos D. et al. Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol. 1988; 12(1): 56–62.


https://doi.org/10.1016/0735-1097(88)90356-7. PMID: 3379219.


28. Burke A.P., Farb A., Malcom G.T. et al. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med. 1997; 336(18): 1276–82.


https://doi.org/10.1056/nejm199705013361802. PMID: 9113930.


29. Davies M.J., Thomas A. Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death. N Engl J Med. 1984; 310(18): 1137–40.


https://doi.org/10.1056/nejm198405033101801. PMID: 6709008.


30. Arbustini E., Grasso M., Diegoli M. et al. Coronary thrombosis in non-cardiac death. Coron Artery Dis. 1993; 4(9): 751–59.


https://doi.org/10.1097/00019501-199309000-00001. PMID: 8287208.


31. Levi M., Keller T.T., van Gorp E., ten Cate H. Infection and inflammation and the coagulation system. Cardiovasc Res. 2003; 60(1): 26–39.


https://doi.org/10.1016/s0008-6363(02)00857-x. PMID: 14522404.


32. Naghavi M., Wyde P., Litovsky S. et al. Influenza infection exerts prominent inflammatory and thrombotic effects on the atherosclerotic plaques of apolipoprotein E-deficient mice. Circulation. 2003; 107(5): 762–68.


https://doi.org/10.1161/01.cir.0000048190.68071.2b. PMID: 12578882.


33. Musher D.M., Abers M.S., Corrales-Medina V.F. Acute infection and myocardial infarction. N Engl J Med. 2019; 380(2): 171–76.


https://doi.org/10.1056/nejmra1808137. PMID: 30625066.


34. Sandoval Y., Jaffe A.S. Type 2 myocardial infarction: JACC review topic of the week. J Am Coll Cardiol. 2019; 73(14): 1846–60.


https://doi.org/10.1016/j.jacc.2019.02.018. PMID: 30975302.


35. Fitzgerald J.R., Foster T.J., Cox D. The interaction of bacterial pathogens with platelets. Nat Rev Microbiol. 2006; 4(6): 445–57.


https://doi.org/10.1038/nrmicro1425. PMID: 16710325.


36. McNicol A., Israels S.J. Beyond hemostasis: The role of platelets in inflammation, malignancy and infection. Cardiovasc Hematol Disord Drug Targets. 2008; 8(2): 99–117.


https://doi.org/10.2174/187152908784533739. PMID: 18537597.


37. Lin C.S., Penha P.D., Zak F.G., Lin J.C. Morphodynamic interpretation of acute coronary thrombosis, with special reference to volcano-like eruption of atheromatous plaque caused by coronary artery spasm. Angiology. 1988; 39(6): 535–47.


https://doi.org/10.1177/000331978803900607. PMID: 3377273.


38. Virmani R., Burke A.P., Farb A., Kolodgie F.D. Pathology of the vulnerable plaque. J Am Coll Cardiol. 2006; 47 (8 Suppl): C13–18.


https://doi.org/10.1016/j.jacc.2005.10.065. PMID: 16631505.


39. Katritsis D.G., Pantos J., Efstathopoulos E. Hemodynamic factors and atheromatic plaque rupture in the coronary arteries: From vulnerable plaque to vulnerable coronary segment. Coron Artery Dis. 2007; 18(3): 229–37.


https://doi.org/10.1097/mca.0b013e328012a93d. PMID: 17429298.


40. Lassila R., Badimon J.J., Vallabhajosula S., Badimon L. Dynamic monitoring of platelet deposition on severely damaged vessel wall in flowing blood: Effects of different stenoses on thrombus growth. Arteriosclerosis. 1990; 10(2): 306–15.


https://doi.org/10.1161/01.atv.10.2.306. PMID: 2317165.


41. Stone P.H. Triggering myocardial infarction. N Engl J Med. 2004; 351(17): 1716–18.


https://doi.org/10.1056/nejmp048245. PMID: 15496619.


42. Ardlie N.G., McGuiness J.A., Garrett J.J. Effect on human platelets of catecholamines at levels achieved in the circulation. Atherosclerosis. 1985; 58(1–3): 251–59.


https://doi.org/10.1016/0021-9150(85)90070-x. PMID: 3004519.


43. Green J., Doughty L., Kaplan S.S. et al. The tissue factor and plasminogen activator inhibitor type-1 response in pediatric sepsis-induced multiple organ failure. Thromb Haemost. 2002; 87(2): 218–23. PMID: 11858480.


44. Vallance P., Collier J., Bhagat K. Infection, inflammation, and infarction: Does acute endothelial dysfunction provide a link? Lancet. 1997; 349(9062): 1391–92.


https://doi.org/10.1016/s0140-6736(96)09424-x. PMID: 9149715.


45. Schouten M., Wiersinga W.J., Levi M., van der Poll T. Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol. 2008; 83(3): 536–45.


https://doi.org/10.1189/jlb.0607373. PMID: 18032692.


46. Owens P., O’Brien E. Hypotension in patients with coronary disease: Can profound hypotensive events cause myocardial ischaemic events? Heart. 1999; 82(4): 477–81.


https://doi.org/10.1136/hrt.82.4.477. PMID: 10490564. PMCID: PMC1760270.


47. Madjid M., Aboshady I., Awan I. et al. Influenza and cardiovascular disease: Is there a causal relationship? Tex Heart Inst J. 2004; 31(1): 4–13. PMID: 15061620. PMCID: PMC387426.


48. Spencer F.A., Goldberg R.J., Becker R.C., Gore J.M. Seasonal distribution of acute myocardial infarction in the second National Registry of Myocardial Infarction. J Am Coll Cardiol. 1998; 31(6): 1226–33.


https://doi.org/10.1016/s0735-1097(98)00098-9. PMID: 9581712.


49. Meier C.R., Jick S.S., Derby L.E. et al. Acute respiratory-tract infections and risk of first-time acute myocardial infarction. Lancet. 1998; 351(9114): 1467–71.


https://doi.org/10.1016/s0140-6736(97)11084-4. PMID: 9605802.


50. Reichert T.A., Simonsen L., Sharma A. et al. Influenza and the winter increase in mortality in the United States, 1959–1999. Am J Epidemiol. 2004; 160(5): 492–502.


https://doi.org/10.1093/aje/kwh227. PMID: 15321847.


51. Bainton D., Jones G.R., Hole D. Influenza and ischaemic heart disease – a possible trigger for acute myocardial infarction? Int J Epidemiol. 1978; 7(3): 231–39.


https://doi.org/10.1093/ije/7.3.231. PMID: 721358.


52. Thompson W.W., Shay D.K., Weintraub E. et al. Influenza-associated hospitalizations in the United States. JAMA. 2004; 292(11): 1333–40.


https://doi.org/10.1001/jama.292.11.1333. PMID: 15367555.


53. Madjid M., Casscells S.W. Of birds and men: Cardiologists’ role in influenza pandemics. Lancet. 2004; 364(9442): 1309.


https://doi.org/10.1016/s0140-6736(04)17176-6. PMID: 15474125.


54. Casscells S.W., Granger E., Kress A.M. et al. Use of oseltamivir after influenza infection is associated with reduced incidence of recurrent adverse cardiovascular outcomes among military health system beneficiaries with prior cardiovascular diseases. Circ Cardiovasc Qual Outcomes. 2009; 2(2): 108–15.


https://doi.org/10.1161/circoutcomes.108.820357. PMID: 20031822.


55. Becker T., Moldoveanu A., Cukierman T., Gerstein H.C. Clinical outcomes associated with the use of subcutaneous insulin-by-glucose sliding scales to manage hyperglycemia in hospitalized patients with pneumonia. Diabetes Res Clin Pract. 2007; 78(3): 392–97.


https://doi.org/10.1016/j.diabres.2007.05.003. PMID: 17597248.


56. Corrales-Medina V.F., Serpa J., Rueda A.M. et al. Acute bacterial pneumonia is associated with the occurrence of acute coronary syndromes. Medicine (Baltimore). 2009; 88(3): 154–59.


https://doi.org/10.1097/md.0b013e3181a692f0. PMID: 19440118.


57. Lamontagne F., Garant M.-P., Carvalho J.-C. et al. Pneumococcal vaccination and risk of myocardial infarction. CMAJ. 2008; 179(8): 773–77.


https://doi.org/10.1503/cmaj.070221. PMID: 18838452. PMCID: PMC2553874.


58. Mitchell I., McNeillis N., Bowden F.J., Nikolic G. Electrocardiographic myocardial infarction pattern in overwhelming post-splenectomy sepsis due to Capnocytophaga canimorsus. Intern Med J. 2002; 32(8): 415–18.


https://doi.org/10.1046/j.1445-5994.2002.00236.x. PMID: 12162399.


59. Scharf C., Widmer U. Image in cardiovascular medicine. Myocardial infarction after dog bite. Circulation. 2000; 102(6): 713–14.


https://doi.org/10.1161/01.cir.102.6.713. PMID: 10931814.


60. Filippatos G., Kardara D., Paramithiotou E. et al. Acute myocardial infarction with normal coronary arteries during septic shock from Neisseria meningitidis. Intensive Care Med. 2000; 26(2): 252.


https://doi.org/10.1007/s001340050058. PMID: 10784321.


61. Arias I.M., Henning T.D., Alba L.M., Rubio S. A meningococcal endocarditis in a patient with Sweet’s syndrome. Int J Cardiol. 2007; 117(1): e51–52.


https://doi.org/10.1016/j.ijcard.2006.11.088. PMID: 17292496.


62. Reynard C.A., Calain P., Pizzolato G.P., Chevrolet J.C. Severe acute myocardial infarction during a staphylococcal septicemia with meningoencephalitis. A possible contraindication to thrombolytic treatment. Intensive Care Med. 1992; 18(4): 247–49.


https://doi.org/10.1007/bf01709842. PMID: 1430592.


63. Svanbom M. A prospective study on septicemia. II: Clinical manifestations and complications, results of antimicrobial treatment and report of a follow-up study. Scand J Infect Dis. 1980; 12(3): 189–206.


https://doi.org/10.3109/inf.1980.12.issue-3.06. PMID: 7433919.


64. Valtonen V., Kuikka A., Syrjänen J. Thromboembolic complications in bacteraemic infections. Eur Heart J. 1993; 14(Suppl K): 20–23. PMID: 8131784.


65. Corrales-Medina V.F., Fatemi O., Serpa J. et al. The association between Staphylococcus aureus bacteremia and acute myocardial infarction. Scand J Infect Dis. 2009; 41(6–7): 511–14.


https://doi.org/10.1080/00365540902913460. PMID: 19396667.


66. Sims J.B., de Lemos J.A., Maewal P. et al. Urinary tract infection in patients with acute coronary syndrome: A potential systemic inflammatory connection. Am Heart J. 2005; 149(6): 1062–65.


https://doi.org/10.1016/j.ahj.2004.08.043. PMID: 15976789.


67. Carrara M., Ferrario M., Bollen Pinto B., Herpain A. The autonomic nervous system in septic shock and its role as a future therapeutic target: A narrative review. Ann Intensive Care. 2021; 11(1): 80.


https://doi.org/10.1186/s13613-021-00869-7. PMID: 33999297. PMCID: PMC8128952.


68. Joffre J., Hellman J., Ince C., Ait-Oufella H. Endothelial responses in sepsis. Am J Respir Crit Care Med. 2020; 202(3): 361–70.


https://doi.org/10.1164/rccm.201910-1911tr. PMID: 32101446.


69. Boisrame-Helms J., Kremer H., Schini-Kerth V., Meziani F. Endothelial dysfunction in sepsis. Curr Vasc Pharmacol. 2013; 11(2): 150–60. PMID: 23506494.


70. Merdji H., Schini-Kerth V., Meziani F., Toti F. Long-term cardiovascular complications following sepsis: Is senescence the missing link? Ann Intensive Care. 2021; 11(1): 166.


https://doi.org/10.1186/s13613-021-00937-y. PMID: 34851467. PMCID: PMC8636544.


71. Walkey A.J., Hammill B.G., Curtis L.H., Benjamin E.J. Long-term outcomes following development of new-onset atrial fibrillation during sepsis. Chest. 2014; 146(5): 1187–95.


https://doi.org/10.1378/chest.14-0003. PMID: 24723004. PMCID: PMC4219336.


72. Felici N., Liu D., Maret J. et al. Long-term abnormalities of lipid profile after a single episode of sepsis. Front Cardiovasc Med. 2021; 8: 674248.


https://doi.org/10.3389/fcvm.2021.674248. PMID: 34869619. PMCID: PMC8634493.


73. Owen A., Patel J.M., Parekh D., Bangash M.N. Mechanisms of post-critical illness cardiovascular disease. Front Cardiovasc Med. 2022; 9: 854421.


https://doi.org/10.3389/fcvm.2022.854421. PMID: 35911546. PMCID: PMC9334745.


74. Garcia M.A., Rucci J.M., Thai K.K. et al. Association between troponin I levels during sepsis and postsepsis cardiovascular complications. Am J Respir Crit Care Med. 2021; 204(5): 557–65.


https://doi.org/10.1164/rccm.202103-0613oc. PMID: 34038701. PMCID: PMC8491250.


75. Martin L., Derwall M., Al Zoubi S. et al. The septic heart: Current understanding of molecular mechanisms and clinical implications. Chest. 2019; 155(2): 427–37.


https://doi.org/10.1016/j.chest.2018.08.1037. PMID: 30171861.


76. Romero-Bermejo F.J., Ruiz-Bailen M., Guerrero-De-Mier M., Lopez-Alvaro J. Echocardiographic hemodynamic monitoring in the critically ill patient. Curr Cardiol Rev. 2011; 7(3): 146–56.


https://doi.org/10.2174/157340311798220485. PMID: 22758613. PMCID: PMC3263479.


77. Masson S., Caironi P., Fanizza C. et al. Sequential N-terminal pro-B-type natriuretic peptide and high-sensitivity cardiac troponin measurements during albumin replacement in patients with severe sepsis or septic shock. Crit Care Med. 2016; 44(4): 707–16.


https://doi.org/10.1097/ccm.0000000000001473. PMID: 26571184.


78. Bessiere F., Khenifer S., Dubourg J. et al. Prognostic value of troponins in sepsis: A meta-analysis. Intensive Care Med. 2013; 39(7): 1181–89.


https://doi.org/10.1007/s00134-013-2902-3. PMID: 23595497.


79. Sato R., Nasu M. A review of sepsis-induced cardiomyopathy. J Intensive Care. 2015; 3: 48.


https://doi.org/10.1186/s40560-015-0112-5. PMID: 26566443. PMCID: PMC4642671.


80. Bosch N.A., Cohen D.M., Walkey A.J. Risk factors for new-onset atrial fibrillation in patients with sepsis: A systematic review and meta-analysis. Crit Care Med. 2019; 47(2): 280–87.


https://doi.org/10.1097/ccm.0000000000003560. PMID: 30653473. PMCID: PMC9872909.


81. Adler A., Topaz G., Heller K. et al. Fever-induced Brugada pattern: How common is it and what does it mean? Heart Rhythm. 2013; 10(9): 1375–82.


https://doi.org/10.1016/j.hrthm.2013.07.030. PMID: 23872691. PMCID: PMC3832740.


82. Parker M.M., Shelhamer J.H., Bacharach S.L. et al. Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med. 1984; 100(4): 483–90.


https://doi.org/10.7326/0003-4819-100-4-483. PMID: 6703540.


83. Clowes G.H. Jr., Vucinic M., Weidner M.G. Circulatory and metabolic alterations associated with survival or death in peritonitis: clinical analysis of 25 cases. Ann Surg. 1966; 163(6): 866–85.


https://doi.org/10.1097/00000658-196606000-00008. PMID: 5933801. PMCID: PMC1477032.


84. Waisbren B.A. Bacteremia due to gram-negative bacilli other than the Salmonella; A clinical and therapeutic study. AMA Arch Intern Med. 1951; 88(4): 467–88.


https://doi.org/10.1001/archinte.1951.03810100051005. PMID: 14867954.


85. Evans L., Rhodes A., Alhazzani W. et al. Surviving sepsis campaign: International guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021; 47(11): 1181–247.


https://doi.org/10.1007/s00134-021-06506-y. PMID: 34599691. PMCID: PMC8486643.


86. Goodman S., Weiss Y., Weissman C. Update on cardiac arrhythmias in the ICU. Curr Opin Crit Care. 2008; 14(5): 549–54.


https://doi.org/10.1097/mcc.0b013e32830a4c5d. PMID: 18787448.


87. Walkey A.J., Evans S.R., Winter M.R., Benjamin E.J. Practice patterns and outcomes of treatments for atrial fibrillation during sepsis: A propensity-matched cohort study. Chest. 2016; 149(1): 74–83.


https://doi.org/10.1378/chest.15-0959. PMID: 26270396. PMCID: PMC4944768.


88. Rhodes A., Evans L.E., Alhazzani W. et al. Surviving sepsis campaign: International guidelines for management of sepsis and septic shock: 2016. Intensive Care Med. 2017; 43(3): 304–77.


https://doi.org/10.1007/s00134-017-4683-6. PMID: 28101605.


89. Overgaard C.B., Dzavík V. Inotropes and vasopressors: Review of physiology and clinical use in cardiovascular disease. Circulation. 2008; 118(10): 1047–56.


https://doi.org/10.1161/circulationaha.107.728840. PMID: 18765387.


90. Madjid M. Acute infections, vaccination and prevention of cardiovascular disease. CMAJ. 2008; 179(8): 749–50.


https://doi.org/10.1503/cmaj.081302. PMID: 18838444. PMCID: PMC2553865.


91. Rudd K.E., Johnson S.C., Agesa K.M. et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: Analysis for the global burden of disease study. Lancet. 2020; 395(10219): 200–11.


https://doi.org/10.1016/s0140-6736(19)32989-7. PMID: 31954465. PMCID: PMC6970225.


92. Lee J.T., Mikkelsen M.E., Qi M., Werner R.M. Trends in post‐acute care use after admissions for sepsis. Ann Am Thorac Soc. 2020; 17(1): 118–21.


https://doi.org/10.1513/annalsats.201905-368rl. PMID: 31532696. PMCID: PMC6944346.


93. Prescott H.C., Osterholzer J.J., Langa K.M. et al. Late mortality after sepsis: Propensity matched cohort study. BMJ. 2016; 353: i2375.


https://doi.org/10.1136/bmj.i2375. PMID: 27189000. PMCID: PMC4869794.


94. Prescott H.C., Angus D.C. Enhancing recovery from sepsis: A review. JAMA. 2018; 319(1): 62–75.


https://doi.org/10.1001/jama.2017.17687. PMID: 29297082. PMCID: PMC5839473.


95. Duazo C., Hsiung J.-C., Qian F. et al. In-hospital cardiac arest in patients with sepsis: A national cohort study. Front Med. 2021; 8: 731266.


https://doi.org/10.3389/fmed.2021.731266. PMID: 34722572. PMCID: PMC8553946.


96. Kosyakovsky L.B., Angriman F., Katz E. et al. Association between sepsis survivorship and long-term cardiovascular outcomes in adults: A systematic review and meta-analysis. Intensive Care Med. 2021; 47(9): 931–42.


https://doi.org/10.1007/s00134-021-06479-y. PMID: 34373953.


Об авторах / Для корреспонденции


Максим Григорьевич Крупин, врач – анестезиолог-реаниматолог ГБУЗ г. Москвы «Московский многопрофильный научно-клинический центр им. С.П. Боткина Департамента здравоохранения города Москвы». Адрес: 125284, г. Москва, 2-й Боткинский проезд, д. 5.
E-mail: dr.m9ut@mail.ru
ORCID: https://orcid.org/0009-0002-9810-8580
Светлана Александровна Близнюк, к. м. н., заведующая кардиологическим отделением для больных с острым инфарктом миокарда, врач-кардиолог, научный сотрудник ГБУЗ г. Москвы «Московский многопрофильный научно-клинический центр им. С.П. Боткина Департамента здравоохранения города Москвы». Адрес: 125284, г. Москва, 2-й Боткинский проезд, д. 5.
E-mail: sabliznyuk@mail.ru
ORCID: https://orcid.org/0000-0002-2619-1592
Арина Сергеевна Жегалина, врач – анестезиолог-реаниматолог ГБУЗ г. Москвы «Московский многопрофильный научно-клинический центр им. С.П. Боткина Департамента здравоохранения города Москвы». Адрес: 125284, г. Москва, 2-й Боткинский проезд, д. 5.
ORCID: https://orcid.org/0009-0005-8047-092X
Анна Григорьевна Комарова, к. м. н., заместитель главного врача по региональному сосудистому центру, ведущий научный сотрудник ГБУЗ г. Москвы «Московский многопрофильный научно-клинический центр им. С.П. Боткина Департамента здравоохранения города Москвы». Адрес: 125284, г. Москва, 2-й Боткинский проезд, д. 5.
E-mail: bellis‑06@mail.ru
ORCID: https://orcid.org/0000-0002-8633-7012
Евгений Петрович Родионов, к. м. н., заместитель главного врача по анестезиологии-реаниматологии, ведущий научный сотрудник ГБУЗ г. Москвы «Московский многопрофильный научно-клинический центр им. С.П. Боткина Департамента здравоохранения города Москвы». Адрес: 125284, г. Москва, 2-й Боткинский проезд, д. 5.
E-mail: dr.rodionov@gmail.com
ORCID: https://orcid.org/0000-0002-3852-8877
Антонина Александровна Плоскирева, профессор РАН, д. м. н., заместитель директора по клинической работе ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора. Адрес: 111123, г. Москва, ул. Новогиреевская, д. 3А.
E-mail: zdk@pcr.ru
ORCID: https://orcid.org/0000-0002-3612-1889


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