Renal Continuum and Blood Proinflammatory Status in Older Patients after Cerebrovascular Accidents
M.M. Mihaleva, E.V. Efremova, A.M. Shutov, A. Al’-Ali, V.V. Gnoevyh
Introduction. The renal continuum is a pressing issue in clinical practice, and its components – acute kidney injury (AKI), acute kidney disease (AKD), and chronic kidney disease (CKD) – are highly prevalent in elderly patients after stroke. Renal dysfunction and cerebrovascular pathology mutually exacerbate each other’s course, increasing the risk of adverse outcomes.
Objective: to assess the prevalence of renal continuum components in elderly patients after acute cerebrovascular accidents.
Materials and methods. This prospective cohort study included 120 patients, 53,3% of whom were men and 46,7% women, with an average age of 68.2 ± 3.8 years, with a history of strokes of various phenotypes less than 6 months old. The data were described using modern statistical analysis methods; differences were considered significant at p < 0.05.
Results. The obtained data show that in the study group of patients, 36.7% had AKI, 25.8% had AKD, and more than half (56.7%) suffered from CKD. Numerous studies in the literature confirm the high frequency of AKI and CKD in patients with acute cerebrovascular accident, while AKD has been very little studied. The results of our study are consistent with existing scientific data.
Conclusion. Among older patients, components of the renal continuum are significantly more common and require increased attention and up-to-date assessment to modify therapy and improve prognosis.
For citation: Mihaleva MM, Efremova EV, Shutov AM, Al Ali A, Gnoevykh VV. Renal continuum and blood proinflammatory status in older patients after cerebrovascular accidents. Therapy (Moscow). 2026;12(5S):39–43.
https://doi.org/10.18565/therapy.2026.5-s5.39-43
Ключевые слова
renal continuum
acute kidney injury
acute kidney disease
chronic kidney disease
cerebrovascular accidents
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Об авторах / Для корреспонденции
Maria M. Mihaleva, MD, postgraduate student, senior lecturer at the Department of internal medicine and occupational diseases of the Institute of Medicine, Ecology and Physical Culture, Ulyanovsk State University, Ulyanovsk, Russian Federation.E-mail: mariam_1810@mail.ru
https://orcid.org/0009-0005-5166-758X. eLibrary SPIN: 5473-6665
Elena V. Efremova, MD, Dr. Sci. (Medicine), associate professor, professor of Department of internal medicine and occupational diseases of the Institute of Medicine, Ecology and Physical Culture, Ulyanovsk State University, Ulyanovsk, Russian Federation.
E-mail: lena_1953@mail.ru
https://orcid.org/0000-0002-7579-4824. eLibrary SPIN: 3548-3443
Alexander M. Shutov, MD, Dr. Sci. (Medicine), professor, head of Department of internal medicine and occupational diseases of the Institute of Medicine, Ecology and Physical Culture, Ulyanovsk State University, Ulyanovsk, Russian Federation.
E-mail: amshu@mail.ru
https://orcid.org/0000-0002-1213-8600. eLibrary SPIN: 4885-9304
Ali Al-Ali, 6th year student of the Institute of Medicine, Ecology and Physical Culture, Ulyanovsk State University, Ulyanovsk, Russian Federation, Syrian Arab Republic
E-mail: ali147852a@yandex-team.ru
https://orcid.org/0009-0000-4046-5660. elibrary SPIN 9662-8432
Valeriy V. Gnoevykh, MD, Dr. Sci. (Medicine), professor, head of the Department of propedeutics of internal diseases of the Institute of Medicine, Ecology and Physical Culture, Ulyanovsk State University, Ulyanovsk, Russian Federation.
E-mail: valvik@inbox.ru
https://orcid.org/0000-0002-8009-0557. eLibrary SPIN: 2247-9609
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