Endotoxin and endothelial dysfunction in patients with heart failure


Yu.V. Konev, L.B. Lazebnik, S.V. Levchenko, L.I. Yefremov

1 A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Department of outpatient therapy, Moscow 2 Moscow clinical scientific practical center, Moscow
The article considers the role of hyperendotoxinemia and systemic inflammation response syndrome as risk factors for the progression of chronic heart failure (CHF). The necessity of joining the gastrointestinal continuum to the existing cardiovascular continuum for expanding and deepening the possibilities of etiopathogenetic correction of CHF is substantiated. It is emphasized that chronic indolent inflammation is an important risk factor for the development of CHF and the progression of atherosclerosis against the background of elevated blood endotoxin levels.
Keywords: gastrointestinal continuum, cardiovascular continuum, endotoxin, systemic inflammatory response, chronic heart failure
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About the Autors

Yuri V. Konev, MD, professor, head of studies of Department of outpatient therapy, A.I. Yevdokimov Moscow State University of Medicine and Dentistry. Address: 127473 Moscow, 20/1, Delegatskaya st. Tel.: +74995536806. E-mail: ukonev@rambler.ru

Leonid B. Lazebnik, MD, professor, Department of outpatient therapy, A.I. Yevdokimov Moscow State University of Medicine and Dentistry. Address: 127473 Moscow, 20/1, Delegatskaya st. Tel.: +74995536806

Svetlana V. Levchenko, PhD, assistant professor of the Department of outpatient therapy, A.I. Yevdokimov Moscow State University of Medicine and Dentistry. Address: 127473 Moscow, 20/1, Delegatskaya St. Tel.: +74956233660

Leonid I. Yefremov, PhD, leading researcher, Moscow clinical scientific practical center. Address: 111123, Moscow, 86 shosse Entuziastov. Tel.: +7495304339


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