Disturbances of water and electrolyte homeostasis as a predictor of an unfavorable long-term prognosis in patients hospitalized for decompensated CHF


K.S. Fazulina, V.V. Fomin, V.V. Meshalkina

1 Federal State Autonomous Educational Institution of Higher Education I. M. Sechenov «First Moscow State Medical University Under the Ministry of Health of the Russian Federation» (Sechenov University), Moscow, Russia 2 Municipal clinical hospital № 24 of Departament of Health care of Moscow, Moscow
Objectives: to investigate correlation between electrolyte imbalance at admission and long-term prognosis. Material and methods: the research based on the data of physical examination, laboratory and instrumental investigation of 111 consecutive patients hospitalized for decompensated heart failure (HF), III–IV functional class NYHA. Results: Mean age 71±12 years; 44,1% were males; 64,0% had emergency admission (IV functional class NYHA), mean left ventricular ejection fraction 41±15%. Electrolyte imbalance at admission was presented in 33,3% of patients. Multivariable survival analysis revealed 2,33-fold independently increased relative risk of all-cause mortality for the patients with electrolyte imbalance at admission [HR 2,33; 95% CI 1,19–7,70; p=0,0201]. Conclusion: in patients hospitalized for decompensated HF, electrolyte imbalance at admission is a predictor of unfavorable prognosis and increased a year mortality.
Keywords: hyperkalemia, potassium, hyponatremia, pathogenesis, sodium, hypokalemia, chronic heart failure, prognosis
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    • About the Autors

    Christina S. Fazulina M.D., сardiologist, applicant of internal medicine №1, Federal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University Under the Ministry of Health of the Russian Federation (Sechenov University). E-mail: kristy874@yandex.ru.

    Victor V. Fomin M.D., Ph.D, professor, corresponding member of the Russian Academy of Science, Vice-Rector for Research and Health-care, chair of internal medicine №1, Federal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University Under the Ministry of Health of the Russian Federation (Sechenov University). E-mail: fomin@mma.ru.

    Viсtoria V. Meshalkina M.D., сardiologist, Municipal clinical hospital №24 of Departament of Health care of Moscow. E-mail: v.meshalkina2017@yandex.ru.


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