New opportunities for chronic heart failure patients’ treatment: Focus at dapagliflosin


DOI: https://dx.doi.org/10.18565/therapy.2023.4.145-152

Malimon V.V., Kokorin V.A.

N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow
Abstract. Chronic heart failure (CHF) still occupies a leading position in the structure of hospitalizations and mortality of patients. Studies of approaches to the treatment of this disease remains to be an urgent problem in the spectrum of attention of the medical community. Inhibitors of sodium-glucose cotransporter type 2 (IGLT-2), originally developed for the treatment of type 2 diabetes mellitus, in recent years are one of the most studied classes of medicines that have proven their efficacy in CHF treatment. Current article describes studied pharmacological mechanisms of iSGLT-2 action, presents an analysis of clinical studies on the use of this class of drugs in patients with CHF. The main attention is paid to the analysis of the DELIVER study, the results of which demonstrated the efficacy of dapagliflozin in treatment of heart failure patients with a moderately reduced and preserved left ventricular ejection fraction.
Keywords: sodium-glucose cotransporter type 2 inhibitors, dapagliflozin, chronic heart failure
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About the Autors

Valentin V. Malimon, assistant at the Department of hospital therapy named after academician P.E. Lukomsky of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: malimon.1993@mail.ru.
ORCID: https://orcid.org/0009-0006-2808-0956
Valentin A. Kokorin, MD, associate Professor, professor of the Department of hospital therapy named after academician P.E. Lukomsky of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: valentinkokorin@yahoo.com. ORCID: https://orcid.org/0000-0001-8614-6542


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