The relationship of endothelin-1 with leading indicators of portal blood flow and central hemodynamics in liver cirrhosis


DOI: https://dx.doi.org/10.18565/therapy.2019.3.49-54

Levitan B.N., Kasyanova T.R., Petelina I.Yu.

Department of faculty therapy and occupational diseases with a course of post-graduate education of Astrakhan State medical University of the Ministry of Healthcare of Russia
The purpose of the study was to identify diagnostic significance of endothelin-1 (ET-1) level definition in patients with liver cirrhosis in connection with portal blood flow and central hemodynamics.
Material and methods. ET-1 level was studied in 115 patients with liver cirrhosis (LC).
Results and conclusion. There was an increase in the values of ET-1 in LC, compared with the control group. The direct connection of ET-1 increase with the activity and degree of liver functional insufficiency and portal hypertension was established. The connection of ET-1 with five types of portal blood flow was found. The greatest changes were observed in hyperkinetic and pseudonormokinetic types, which are considered to be the most unfavorable. In patients with LC revealed the relationship between changes in ET-1 and the number of parameters of central blood flow.
Keywords: central blood flow, portal blood flow, portal hypertension, liver cirrhosis, endothelin-1
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About the Autors

Boleslav N. Levitan, MD, professor, Head of the Department of faculty therapy and occupational diseases with a course of post-graduate education of Astrakhan State medical University of the Ministry of Healthcare of Russia. Address: 414000, Astrakhan, 121 Bakinskaya Str. Tel.: +7 (908) 616-91-85. E-mail: bolev@mail.ru
Tatiana R. Kasyanova, MD, associate professor of the Department of faculty therapy and occupational diseases with a course of post-graduate education of Astrakhan State medical University of the Ministry of Healthcare of Russia. Address: 414000, Astrakhan, 121 Bakinskaya Str. Tel.: +7 (8512) 28-90-75; +7 (905) 361-51-27. E-mail: kasyanova.tatjana@yandex.ru
Ilona Yu. Petelina, PhD, associate professor of the Department of faculty therapy and occupational diseases with a course of post-graduate education of Astrakhan State medical University of the Ministry of Healthcare of Russia. Address: 414000, Astrakhan, 121 Bakinskaya Str. Tel.: +7 (8512) 28-90-75; +7 (917) 096-68-15. E-mail: piy2008@yandex.ru


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