Intrahepatic cholestasis of pregnancy


DOI: https://dx.doi.org/10.18565/therapy.2020.1.85-95

Polunina T.E., Tazitdinov R.Kh.

1) A.I. Yevdokimov Moscow State University of medicine and dentistry of the Ministry of Healthcare of Russia; 2) FMBA of Russia Federal scientific clinical Center of specialized forms of medical care and medical technology, Moscow
Liver plays vitally important role in the well-being of the mother and fetus. Intrahepatic cholestasis of pregnancy (ICP) has a different prevalence throughout the world and is the most common liver disease in pregnancy. The etiology of this pathology is not fully studied yet, since its development is influenced by numerous factors, including genetic mutations, hormonal changes and environmental influences.
The disease often manifests itself in the third trimester of pregnancy with generalized itching and spontaneous relief in the postpartum period. This condition is associated with a high probability of complications during pregnancy and also fetal mortality. The diagnosis of ICP is based on the clinical picture in combination with biochemical abnormalities of liver function.
An increase in the total level of bile acids is the most common laboratory anomaly and, due to that, the most important indicator for choosing treatment tactics and determining the most suitable gestational period for deliveries in case of ICP status. Current article discusses the epidemiology, possible etiology and pathogenesis, clinical features, diagnosis and treatment of ICP.
Keywords: liver damage, intrahepatic cholestasis of pregnancy, ursodeoxycholic acid, pregnancy
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About the Autors

Tatyana E. Polunina, MD, professor of the Department of propaedeutics of internal diseases and gastroenterology of A.I. Evdokimov Moscow State University of medicine and dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya Str. Tel.: +7 (495) 609-67-00. E-mail: poluntan@mail.ru
Renat Kh. Tazitdinov, obstetrician of FMBA of Russia Federal scientific clinical Center of specialized forms of medical care and medical technology. Address: 115682, Moscow, 28 Orekhovy avenue. Tel.: +7 (499) 725-44-40.


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