Thickness of the intima-media complex of carotid arteries in patients with extraskeletinal manifestations of spondyloarthritis


DOI: https://dx.doi.org/10.18565/therapy.2022.2.19-23

Rebrov A.P., Aparkina A.V., Gamayunova K.A.

V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia
Abstract. The presence of uveitis is one of the risk factors for cardiovascular pathology development in patients with spondyloarthritis (SpA).
The aim of the study was to compare the intima-media complex thickness (IMT) of common carotid artery in SpA patients with and without uveitis.
Material and methods. The study included 69 patients with SpA meeting ASIS axial spondyloarthritis criteria (2009), including 48 persons (69,6%) with ankylosing spondylitis (AS), 6 (8,7%) with undifferentiated SpA, 15 (21,7%) – with psoriatic arthritis. 30 (43,5%) patients were monitored by ophthalmologist for uveitis; the duration of uveitis was 10.5 [8; 14,5] years. At the time of inclusion in the study, patients with SpA did not have features of active uveitis. Patients with and without uveitis were comparable in terms of sex, age, duration of the disease, age of onset of the disease, BMI, systolic and diastolic blood pressure levels, blood lipid spectrum parameters.
Results. The average IMT of the carotid arteries in all patients with SpA was 0.67 [0,57; 0,82] mm; in patients with uveitis, this index was 0,74 [0,58; 0,96] mm, without uveitis – 0,6 [0,55; 0,65] mm (p=0,003). Thickening of the carotid intima-media complex >0,9 mm and the presence of atherosclerotic plaques were found in 13 (43,3%) patients with uveitis and in 7 (17,95%) without uveitis (p=0,041; χ2=4,14). Atherosclerotic plaques were found in 7 patients with uveitis and 4 without uveitis. In 10 (76,9%) of 13 patients with uveitis and the presence of carotid intima-media thickening >0,9 mm and/or the presence of atherosclerotic plaques, the side of carotid artery lesions corresponded to the side of uveitis localization.
Conclusion. SpA patients with uveitis have increase in IMT of the carotid arteries more often, while the side of the lesion of the carotid arteries mainly corresponds to the side of the localization of uveitis.

Literature


1. Garcia-Vicuna R., Zarco P., Gonzalez C.M. et al. Two year incidence of psoriasis, uveitis and inflammatory bowel disease in patients with spondyloarthritis: A study in the AQUILES cohort. Reumatol Clin. 2016; 12(1): 22–26. http://dx.doi.org/10.1016/j.reumae.2015.03.011.


2. Sungur G., Yakin M., Uzman S. et al. Clinical features and prognosis of uveitis in a Turkish patient population with ankylosing spondylitis: Incidence and management of ocular complications. Ocul Immunol Inflamm. 2019; 27(4): 551–59. http://dx.doi.org/10.1080/09273948.2018.1431290.


3. Дубинина Т.В., Эрдес Ш.Ф. Эффективность голимумаба в лечении увеита у больных анкилозирующим спондилитом. Современная ревматология. 2016; 3: 77–80. [Dubinina T.V., Erdes S.F. Efficacy of golimumab in treating uveitis in patients with ankylosing spondylitis. Sovremennaya revmatologiya = Modern Rheumatology Journal. 2016; 3: 77–80 (In Russ.)]. http://dx.doi.org/10.14412/1996-7012-2016-3-77-80.


4. Van Denderen J.C., Visman I.M., Nurmohamed M.T. et al. Adalimumab significantly reduces the recurrence rate of anterior uveitis in patients with ankylosing spondylitis. J Rheumatol. 2014; 41(9): 1843–48. http://dx.doi.org/10.3899/jrheum.131289.


5. Bacchiega A.B.S., Balbi G.G.M., Ochtrop M.L.G. et al. Ocular involvement in patients with spondyloarthritis. Rheumatology. 2017; 56(12): 2060–67. http://dx.doi.org/10.1093/rheumatology/kex057.


6. Ребров А.П., Апаркина А.В., Акулова И.А. с соавт. Особенности диагностики анкилозирующего спондилита при наличии увеита у лиц разного пола. Современная ревматология. 2014; 4: 14–16. [Rebrov A.P., Aparkina A.V., Akulova I.A. et al. Specific features of diagnosis of ankylosing spondylitis inthe presence of uveitis in persons of differentsex. Sovremennaya revmatologiya = Modern Rheumatology Journal. 2014; 4: 14–16 (In Russ.)]. http://dx.doi.org/10.14412/1996-7012-2014-4-14-16.


7. Годзенко А.А., Бочкова А.Г., Румянцева О.А. с соавт. Взаимосвязь между поражением сердца и другими клиническими проявлениями анкилозирующего спондилита. Научно-практическая ревматология. 2010; 5: 32–36. [Godzenko A.A., Bochkova A.G., Rumyantseva O.A., et al. Association between cardiac lesion and other clinical manifestationsof ankylosing spondylitis. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2010; 5: 32–36 (In Russ.)]. http://dx.doi.org/10.14412/1995-4484-2010-728.


8. Uslu A.U., Kucuk A., Balta S. et al. The relation between ischemia modified albumin levels and carotid intima media thickness inpatients with rheumatoid arthritis. Int J Rheum Dis. 2019; 22(1): 32–37. http://dx.doi.org/10.1111/1756-185X.12851.


9. Balta S., Aparci M., Ozturk C. et al. Carotid intima media thickness and subclinical early atherosclerosis. Int J Cardiol. 2016; 203: 1146. http://dx.doi.org/10.1016/j.ijcard.2015.11.025.


10. Verma I., Krishan P., Syngle A. Predictors of atherosclerosis in ankylosing spondylitis. Rheumatol Ther. 2015; 2(2): 173–82. http://dx.doi.org/10.1007/s40744-015-0017-8.


11. Skare T.L., Verceze G.C., Oliveira A.A. et al. Carotid intima-media thickness in spondyloarthritis patients. Sao Paulo Med J. 2013; 131(2):100–5. http://dx.doi.org/10.1590/S1516-31802013000100020.


12. Stanek A., Cholewka A., Wielkoszynski T. et al. Increased levels of oxidative stress markers, soluble cd40 ligand, and carotid intima-media thickness reflect acceleration of atherosclerosis in male patients with ankylosing spondylitis inactive phase and without the classical cardiovascular risk factors. Oxid Med Cell Longev. 2017; 2017: 9712536. http://dx.doi.org/10.1155/2017/9712536.


13. Polak J.F., Person S.D., Wei G.S. et al. Segment-specific association of carotid intima-media thickness with cardiovascular riskfactors. The Coronary Artery Risk development in Young Adult (CARDIA) Study. Stroke. 2010; 41(1): 9–15. http://dx.doi.org/10.1161/STROKEAHA.109.56659642.


14. Tyrrell P.N., Beyene J., Feldman B.M. et al. Rheumatic disease and carotid intima-mediathickness: A systematic review and meta-analysis. Arterioscler Thromb Vasc Biol. 2010; 30(5):1014–26. http://dx.doi.org/10.1161/ATVBAHA.109.198424.


15. van Sijl A.M., Peters M.J., Knol D.K. et al. Carotid intima media thickness in rheumatoid arthritis as compared to control subjects: A meta-analysis. Semin Arthritis Rheum. 2011; 40(5): 389–97. http://dx.doi.org/10.1016/j.semarthrit.2010.06.00644.


16. 1Ristic G.G., Subota V., Lepic T. et al. Subclinical atherosclerosis in patients with rheumatoid arthritis and low cardiovascular risk: The role of von Willebrand factor activity. PLoS One. 2015;10(8): e0130462. http://dx.doi.org/10.1371/journal.pone.0130462.


17. Agca R., Heslinga S.C., Rollefstad S. et al. EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update. Ann Rheum Dis. 2017; 76(1): 17–28. http://dx.doi.org/10.1136/annrheumdis-2016-209775.


18. Gonzalez-Gay M.A., Gonzalez-Juanatey C., Pineiro A. et al. High-grade C-reactive protein elevation correlates with accelerated atherogenesis in patients with rheumatoid arthritis. J Rheumatol. 2005; 32(7): 1219–23.


About the Autors


Andrey P. Rebrov, MD, professor, head of the Department of hospital therapy of the Faculty of general medicine, V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia, authorized representative of the Russian Scientific Medical Society of Internal Medicine in the Volga Federal District. Address: 410012, Saratov, 112 Bol’shaya Kazach’ya Str. E-mail: andreyrebrov@yandex.ru. ORCID: https://orcid.org/0000-0002-3463-7734
Alena V. Aparkina, PhD, assistant at the Department of hospital therapy of the Faculty of general medicine, V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia. Address: 410012, Saratov, 112 Bol’shaya Kazach’ya Str. E-mail: alena437539@yandex.ru. ORCID: https://orcid.org/0000-0001-8463-2379
Kristina A. Gamayunova, postgraduate student at the Department of hospital therapy of the Faculty of general medicine, V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia. Address: 410012, Saratov, 112 Bol’shaya Kazach’ya Str. E-mail: k.a.gamayunova@mail.ru


Similar Articles


Бионика Медиа