Features of kidney function in patients with a novel coronavirus infection COVID-19


DOI: https://dx.doi.org/10.18565/therapy.2022.7.15-20

Kichigin V.A., Abyzov A.S., Chepurnaya O.P.

I.N. Ulyanov Chuvash State University, Cheboksary
Abstract. The novel coronavirus infection COVID-19 is characterized by multiple organ damage, including kidney damage.
The aim of the study was to establish the incidence of acute kidney injury (AKI) and chronic kidney disease (CKD), their association with clinical and laboratory parameters, and their association with death in patients with COVID-19.
Material and methods. The study was conducted on the basis of an emergency hospital (Cheboksary). We analyzed 182 hospitalized cases of COVID-19 patients, of whom 82 died.
Results. In patients with COPD-19, proteinuria more than 0,1 g/l (69,8%) and erythrocyturia more than 3 (50,5%) are often noted. Blood creatinine (>91,8 µmol/l, RR 1,95), glomerular filtration rate (GFR <63,8 ml/min, RR 2,55), erythrocyturia (>3/μl, RR 3,03), proteinuria (>0,1 g/µl, RR 5,82), going beyond which significantly increases the relative risk (RR) of death. In patients with COVID-19, CKD (52,7%, of which 21,4% with CKD stages 3–4) and AKI (17,6%, including 13,2% against the background of previous CKD) are more often recorded. Risk factors for the development of AKI in patients with COVID-19 were the presence of CKD, advanced age, and the development of CKD – advanced age.
Conclusion. The presence of AKI and chronic renal failure is characterized by more pronounced clinical manifestations, laboratory changes, more frequent need for oxygen therapy and mechanical ventilation. Risk factors for death are both AKI (RR 2,57) and CKD (RR 1,64).
Keywords: novel coronavirus infection, chronic kidney disease, acute kidney injury, mortality
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About the Autors

Vadim A. Kichigin, PhD in Medicine, associate professor, associate professor of the Department of faculty and hospital therapy, I.N. Ulyanov Chuvash State University. Address: 428015, Cheboksary, 15 Moskovsky Avenue. E-mail: vadim-kichigin@mail.ru. ORCID: https://orcid.org/0000-0002-9161-2066
Alexey S. Abyzov, assistant at the Department of faculty and hospital therapy, I.N. Ulyanov Chuvash State University. Address: 428015, Cheboksary, 15 Moskovsky Avenue. E-mail: medikchuvsu@yandex.ru.
ORCID: https://orcid.org/0000-0002-3770-9414
Oksana P. Chepurnaya, PhD in Medicine, associate professor, associate professor of the Department of faculty and hospital therapy, I.N. Ulyanov Chuvash State University. Address: 428015, Cheboksary, 15 Moskovsky Avenue. E-mail: chepurnaya.oxana@yandex.ru. ORCID: https://orcid.org/0000-0002-5725-5747


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