MicroRNA-1 and microRNA-133: Small moleculesof great importance in the aspect of cardiovascular diseases


DOI: https://dx.doi.org/10.18565/therapy.2023.2.72-79

Alieva A.M., Teplova N.V., Butenko A.V., Averin E.E., Akhmedova M.F., Shikhova Yu.A., Valiev R.K., Saryev M.N., Kotikova I.A., Nikitin I.G.

1) N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow; 2) Academician B.V. Petrovsky Russian Scientific Center of Surgery of the Ministry of Education and Science of Russia, Moscow; 3) AKFA Medline Clinic, Tashkent; 4) A.S. Loginov Moscow Clinical Research Center of the Department of Healthcare of Moscow
Abstract. Fundamental and clinical studies have clearly demonstrated the importance of microRNA (miRNA) in cell differentiation, growth, proliferation and apoptosis regulation. This effect of miRNA extends to the cardiovascular system as well. Experimental studies have shown the participation of miRNA both in the normal development of the heart and blood vessels, and in the formation of such pathological conditions as myocardial hypertrophy and its remodeling, circulatory failure. MiRNAs are involved in mobilization of progenitor cells and other supporting cells from the bone marrow into peripheral blood circulation, which is an important part in restoring heart function after ischemic damage. The presented literature review points at the potentially important diagnostic and prognostic value of miRNA-1 and miRNA-133 evaluation.
Keywords: cardiac hypertrophy, microRNA, biological markers, arrhythmia, coronary heart disease
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About the Autors

Amina M. Aliyeva, PhD in Medical Sciences, associate professor of the Department of hospital therapy named after academician G.I. Storozhakov of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: amisha_alieva@mail.ru. ORCID: https://orcid.org/0000-0001-5416-8579. SPIN: 2749-6427
Natalya V. Teplova, MD, professor, head of the Department of clinical pharmacology of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. ORCID: https://orcid.org/0000-0002-7181-4680
Aleksey V. Butenko, MD, professor, chief physician of the scientific and clinical Center No.2, Academician
B.V. Petrovsky Russian Scientific Center of Surgery of the Ministry of Education and Science of Russia. Address: 117593, Moscow, 1a Litovsky Boulevard
Evgeniy E. Averin, MD, head of the scientific and educational Center of the scientific and clinical Center No.2, Academician B.V. Petrovsky Russian Scientific Center of Surgery of the Ministry of Education and Science of Russia. Address: 117593, Moscow, 1a Litovsky Boulevard. ORCID: https://orcid.org/0000-0002-6595-6471
Madina F. Akhmedova, PhD in Medical Sciences, cardiologist at the Department of adult cardiac surgery, AKFA Medline Clinic (Tashkent city). E-mail: drmadina@yandex.ru. ORCID: https://orcid.org/0000-000206184-6742
Yulia A. Shikhova, PhD in Medical Sciences, deputy chief physician for medical work of the scientific and clinical Center No. 2, Academician B.V. Petrovsky Russian Scientific Center of Surgery of the Ministry of Education and Science of Russia. Address: 117593, Moscow, 1a Litovsky Boulevard. ORCID: https://orcid.org/0000-0003-4688-4385
Ramiz K. Valiev, PhD in Medical Sciences, head of oncosurgical Department No. 2, A.S. Loginov Moscow Clinical Research Center of the Department of Healthcare of Moscow. Address: 111123, Moscow, 86 Entuziastov Highway. E-mail: radiosurgery@bk.ru. ORCID: https://orcid.org/0000-0003-1613-3716. SPIN: 2855-2867
Muhammetsakhet N. Sariyev, oncologist at A.S. Loginov Moscow Clinical Research Center of the Department of Healthcare of Moscow. Address: 111123, Moscow, 86 Entuziastov Highway. E-mail: mishamoff@gmail.com. ORCID: https://orcid.org/0000-0003-1794-9258
Irina A. Kotikova, student of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: kotikova.ia@mail.ru. ORCID: https://orcid.org/0000-0001-5352-8499. SPIN: 1423-7300
Igor G. Nikitin, MD, professor, head of the Department of hospital therapy named after academician G.I. Storozhakov of the Faculty of general medicine, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. E-mail: igor.nikitin.64@mail.ru. ORCID: https://orcid.org/0000-0003-1699-0881


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