Asymptomatic hyperuricemia in the practice of endocrinologist: Pleiotropic action of antihyperglycemic drugs


DOI: https://dx.doi.org/10.18565/therapy.2024.8.96-104

Yuzhakova E.V., Shanko Zh.G., Smirnova E.N.

Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia
Abstract. Asymptomatic hyperuricemia (AH) is a common laboratory finding in comorbid patients. Currently, AH is considered to be an independent component of metabolic syndrome (MS), affecting the outcomes of cardiac pathology. Detection and correction of AH in patients with type 2 diabetes mellitus is an important task of the therapeutic care. In treatment of comorbid patients, the idea of selecting drugs with pleiotropic effects affecting different components of MS, including those that help reduce uric acid levels, is very actual. Among hypoglycemic drugs, the hypouricemic effect has been described for sodium-glucose co-transporter type 2 inhibitors, dipeptidyl peptidase type 4 inhibitors, and thiazolidinediones. The use of drugs with pleiotropic action will potentially reduce the dose of allopurinol. Influence of combinations of these groups of hypoglycemic drugs at AH should be the subject of further research works.

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About the Autors


Ekaterina V. Yuzhakova, MD, PhD (Medicine), associate professor of the Department of endocrinology and clinical pharmacology, Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia. Address: 614045, Perm, 55 Pushkina St.
E-mail: uzkaty@mail.ru
ORCID: https://orcid.org/0000-0001-5262-9378
Zhanna G. Shanko, MD, PhD (Medicine), assistant at the Department of endocrinology and clinical pharmacology, Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia. Address: 614045, Perm, 55 Pushkina St.
E-mail: zhshanco@gmail.com
ORCID: https://orcid.org/0009-0003-7873-0505
Elena N. Smirnova, MD, Dr. Sci. (Medicine), professor, head of the Department of endocrinology and clinical pharmacology, Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia. Address: 614045, Perm, 55 Pushkina St.
E-mail: elenasm2001@mail.ru
ORCID: https://orcid.org/0000-0003-2727-5226


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