Bronchial asthma with fixed respiratory obstruction: The problem and ways of its solution


DOI: https://dx.doi.org/10.18565/therapy.2024.9.118-129

Karoli N.A., Sazhnova S.I.

V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia
Abstract. Bronchial asthma (BA) is a chronic inflammatory disease of the respiratory tract with various phenotypes. Phenotype associated with a severe, difficult-to-control course of the disease is BA with fixed respiratory obstruction (FRO). The high risk of exacerbations, difficulty in achieving control and the severity of asthma in such kind of patients are occurring due to damage of the peripheral airways. In this regard, the main therapeutic target for this disease is the distal parts of bronchial tree, and the efficacy of inhalation therapy depends on the degree of drug deposition in them. Extrafine fixed combination of beclomethasone dipropionate, formoterol and glycopyrronium bromide affects inflammation in the distal bronchial tree and is of priority in the treatment of patients with severe bronchial asthma and FRO helping to achieve disease control.
Keywords: fixed respiratory obstruction, beclomethasone dipropionate, glycopyrronium bromide, triple therapy, formoterol, bronchial asthma
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About the Autors

Nina A. Karoli, MD, Dr. Sci. (Medicine), professor of the Department of hospital therapy of the Faculty of general medicine, V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia. Address: 410012, Saratov, 112 Bol’shaya Kazachya St.
E-mail: nina.karoli.73@gmail.com
ORCID: https://orcid.org/0000-0002-7464-826X
Svetlana I. Sazhnova, MD, PhD (Medicine), associate professor of the Department of hospital therapy of the Faculty of general medicine, V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia. Address: 410012, Saratov, 112 Bol’shaya Kazachya St.
E-mail: sazhnova.svetlana@mail.ru
ORCID: https://orcid.org/0000-0002-3765-4812


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