Active tuberculosis process in female patient with asymptomatic clinical course of malignant neoplasm in the pulmonary tissue


DOI: https://dx.doi.org/10.18565/therapy.2025.1.134-139

Chumovatov N.V., Ainsanova A.A., Chernykh N.A., Khozikov A.S., Komissarova O.G.

1) Central Research Institute of Tuberculosis, Moscow; 2) N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow
Abstract. In modern phthisiology, the problem of combination of pulmonary tuberculosis and malignant neoplasms (MN) is actual. According to research data, in case of MN, the risk of tuberculosis arising in patients increases by 6 times. At the same time, the presence of an active tuberculosis process (ATP) in lung tissue increases the probability of lung cancer by 3 times or more. In addition, the interaction of these two diseases can reduce the anti-tumor effect of immune system. This situation can lead to a long-term asymptomatic clinical course of oncological process coming secondary to active pulmonary tuberculosis. The aim of the article is to demonstrate the combination of ATP and asymptomatic clinical course of malignant neoplasms. The presented clinical example demonstrates the difficulties of diagnosis and choice of treatment tactics in such category of patients. Actual direction in modern phthisiology is high oncological alertness to comorbid patients with pulmonary tuberculosis.
Keywords: asymptomatic course, malignant neoplasms, differential diagnostics, tuberculosis
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About the Autors

Nikita V. Chumovatov, MD, PhD (Medicine), researcher at the Department of phthisiology, Central Research Institute of Tuberculosis. Address: 107564, Moscow, 2 Yauzskaya Alley.
E-mail: Necro5412@mail.ru
ORCID: https://orcid.org/0000-0001-8745-7940
Asel A. Ainsanova, MD, laboratory assistant-researcher at the Department of phthisiology, Central Research Institute of Tuberculosis. Address: 107564, Moscow, 2 Yauzskaya Alley.
E-mail: asel.ainsanova@gmail.com
ORCID: https://orcid.org/0009-0001-5593-6872
Natalya A. Chernykh, MD, PhD (Medicine), senior researcher at the Department of phthisiology, Central Research Institute of Tuberculosis. Address: 107564, Moscow, 2 Yauzskaya Alley.
E-mail: natadok@inbox.ru
ORCID: https://orcid.org/0000-0001-6787-2362
Andrey S. Khozikov, MD, pathologist at Central Research Institute of Tuberculosis. Address: 107564, Moscow, 2 Yauzskaya Alley.
E-mail: hozikov96@mail.ru
ORCID: https://orcid.org/0000-0003-0308-9592
Oksana G. Komissarova, MD, Dr. Sci. (Medicine), associate professor, deputy director for scientific and medical work of the Department of phthisiology, Central Research Institute of Tuberculosis, professor of the Department of phthisiology, N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 107564, Moscow, 2 Yauzskaya Alley.
E-mail: oksana.komissarova.72@mail.ru
ORCID: https://orcid.org/0000-0003-4427-3804


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