Поздняя лимбическая ТДП-43 энцефалопатия: новая нозологическая форма деменции


DOI: https://dx.doi.org/10.18565/therapy.2021.8.164-171

Е.А. Катунина

1) ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, г. Москва; 2) ФГБУ «Федеральный центр мозга и нейротехнологий» ФМБА России, г. Москва
Аннотация. Увеличение средней продолжительности жизни – одна из причин роста распространенности когнитивных расстройств, прежде всего связанных с нейродегенеративными заболеваниями. Развитие методов структурной и функциональной нейровизуализации, технологий гистохимических исследований позволили выделить новые формы деменции, обусловленные накоплением токсичных белковых продуктов. К числу таких деменций относится поздняя лимбическая ТДП-43 энцефалопатия, диагностические критерии которой были опубликованы в 2019 г. Отличительными ее чертами являются позднее начало (у лиц в возрасте 80 лет и старше), преобладание амнестического синдрома при отсутствии речевых и поведенческих расстройств, а также частое ее сочетание с гиппокампальным склерозом. Предлагаемый обзор посвящен патогенетическим и клиническим особенностям этой новой формы деменции.
Ключевые слова: ТДП-43 протеинопатия, поздняя лимбическая энцефалопатия, мемантин, деменция
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Об авторах / Для корреспонденции

Елена Анатольевна Катунина, д.м.н., профессор, профессор кафедры неврологии, нейрохирургии и медицинской генетики лечебного факультета ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, руководитель отдела нейродегенеративных заболеваний ФГБУ «Федеральный центр мозга и нейротехнологий» ФМБА России. Адрес: 119415, г. Москва, Островитянова ул., д. 1., стр. 10. E-mail: elkatunina@mail.ru


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