Глифлозины при неалкогольной жировой болезни печени: перспективы применения за границами диабета, кардио- и нефропротекции


DOI: https://dx.doi.org/10.18565/therapy.2023.7.130-141

В.А. Приходько, С.В. Оковитый, А.Н. Куликов

1) ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России; 2) ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова» Минздрава России
Аннотация. Глифлозины (ингибиторы натрий-глюкозных котранспортеров, SGLT) на сегодняшний день являются одной из наиболее многочисленных групп противодиабетических средств. Помимо прямого гипогликемизирующего действия, для этих препаратов установлено наличие широкого спектра плейотропных эффектов, из которых наибольшую известность имеют кардиои ренопротекторный. В последнее десятилетие не меньшее внимание исследователей привлекала способность глифлозинов оказывать благоприятное влияние на течение неалкогольной жировой болезни печени (НАЖБП), реализуемое через ряд вторичных механизмов. Настоящий обзор содержит данные об особенностях гепатопротекторного действия глифлозинов, а также анализ современного ландшафта клинических исследований этой группы препаратов при НАЖБП.

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Об авторах / Для корреспонденции


Вероника Александровна Приходько, ассистент кафедры фармакологии и клинической фармакологии ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России. Адрес: 197022, г. Санкт-Петербург, ул. Профессора Попова, д. 14, лит. А.
E-mail: veronika.prihodko@pharminnotech.com ORCID: https://orcid.org/0000-0002-4690-1811
Сергей Владимирович Оковитый, д.м.н., профессор, зав. кафедрой фармакологии и клинической фармакологии ФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава России. Адрес: 197022, г. Санкт-Петербург, ул. Профессора Попова, д. 14, лит. А.
E-mail: sergey.okovity@pharminnotech.com ORCID: https://orcid.org/0000-0003-4294-5531
Александр Николаевич Куликов, д.м.н., профессор, зав. кафедрой пропедевтики внутренних болезней ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова» Минздрава России. Адрес: 197022, г. Санкт-Петербург, ул. Льва Толстого, д. 6–8.
E-mail: ankulikov2005@yandex.ru
ORCID: https://orcid.org/0000-0002-4544-2967


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