Dayly dynamics of indices of central aortic pressure and arterial stiffness in patients with arterial hypertension in the composition of a metabolic syndrome at the background of a fixed-dose combination of perindopril arginine and indapamide


L.A. Andreeva, L.A. Panchenkova, A.I. Martynov, E.A. Troshina, K.A. Khamidova, E.E. Kazanceva, L.A. Medvedeva, G.G. Karnuta, T.E. Yurkova

1 Road Clinical Hospital. N.А. Semashko at the metro station Lublino RZD, Moscow; 2 Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Department of Hospital Therapy № 1, Moscow; 3 Endocrinology Research Center of RAMS, Moscow; 4 FGBU “Polyclinic № 1” Administration of the President of the Russian Federation, Moscow
Aim of the research work. Analysis of the influence of perindopril arginine and indapamide fixed combination at daily dynamics of central aortal pressure and arterial rigidity indexes in patients with metabolic syndrome-associated arterial hypertension. Material and methods. 22 patients with metabolic syndrome-associated essential arterial hypertension (average age 50 years old) were involved in the study. All of them did not have antihypertensive therapy before or passed through 3-7 days of washout period. Estimation of central aortal pressure and arterial rigidity indexes was performed before start of the therapy and after 16-weeks of perindopril arginine and indapamide (2,5/0,625, 5/1,25, 10/2,5 mg) fixed combination intake. Results. On the top of administered therapy it was fixed the statistically significant decrease of central aortal pressure indexes (systolic, diastolic and pulse pressure) at 13,7, 8,5 and 5,3 mm Hg respectively; and aortic pulse wave velocity – at 0.7 m/sec. Peripheral systolic arterial pressure decreased at 24,7, diastolic – at 8, and pulse pressure – at 7 mm Hg. Conclusion. Taking into consideration the significant antihypertensive efficacy concerning both peripheral arterial pressure and central aortal pressure, which is not accompanied by hypotension episodes, and also the fact of positive influence of medicaments at resilient-elastic characteristics of the arteries, metabolic neutrality and good acceptability, one can say, that fixed combination of perindopril arginine and indapamid could be prescribed for the wide range of arterial hypertension patients including cases with metabolic syndrome.
Keywords: central aortic pressure, perindopril arginine, augmentation index, pulse wave velocity, indapamide, arterial stiffness, metabolic syndrome, arterial hypertension
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    • About the Autors

    Lyaysan A. Andreeva, therapist FGBU “Polyclinic № 1” UD of the President of the Russian Federation, 119002, Moscow, per. Sivtsev Vrazhek, 26/28; The post-graduate student of the Department of Hospital Therapy No. 1 of MGMSU. A.I. Evdokimova; 109386, Moscow, Stavropol ul., Domovl. 23, building. 1. Tel.: +74956208101. E-mail: arfelia_marnessa@mail.ru
    Lyudmila A. Panchenkova, MD, professor of the Department of Hospital Therapy № 1 MGMSU. A.I. Evdokimova; 109386, Moscow, Stavropol ul., Domovl. 23, building. 1

    Anatoly I. Martynov, аcademician of the Russian Academy of Medical Sciences, MD, professor of the Department of Hospital Therapy No. 1 of MGMSU, Honored Scientist of the Russian Federation, Honored Doctor of the Russian Federation, Laureate of the USSR Government Prize, Member of the Presidium of the All-Russian Scientific Society of Cardiology, Chief Specialist of the Medical Center of the Presidential Administration The Russian Federation; 109386, Moscow, Stavropol ul., Domovl. 23, building. 1

    Ekaterina A. Troshina, MD, Professor, Corresponding Member of the Russian Academy of Sciences, doctor of the highest qualification category, chief research officer of the Endocrinology Research Center of RAMS. 117036, Moscow, Dmitriya Ylyanova str. 11

    Khadizhat A. Khamidova, Ph.D., assistant of the Department of Hospital Therapy No. 1 of Moscow State Medical University. A.I. Evdokimova; 109386, Moscow, Stavropol str., Domovl. 23, building. 1

    Elizaveta E. Kazantseva, MD, head of the endocrinology department, endocrinologist of the Road Clinical Hospital. N.А. Semashko at the metro station Lublino RZD; 109386, Moscow, Stavropol str., Domovl. 23, building. 1

    Lyudmila A. Medvedeva, an endocrinologist of the Road Clinical Hospital. N.А. Semashko at the metro station Lublino RZD; 109386, Moscow, Stavropol str., Domovl. 23, building. 1

    Galina G. Karnuta, MD, head of the gastroenterology department, a gastroenterologist, a physician-therapist of the highest qualification category of the Road Clinical Hospital. N.А. Semashko at the metro station Lublino RZD; 109386, Moscow, Stavropol str., Domovl. 23, building. 1

    Tatyana E. Yurkova, Ph.D., assistant of the Department of Hospital Therapy № 1 MGMSU. A.I. Evdokimova, Road Clinical Hospital. N.А. Semashko at the metro station Lublino RZD; 109386, Moscow, Stavropol str., Domovl. 23, building. 1


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