Hemostais, adipokines, rennin-angiotensin system gene polymorphisms and target organ damage in young patients with hypertension and abdominal obesity


DOI: https://dx.doi.org/10.18565/therapy.2019.1.82-88

Chulkov Vl.S., Vereina N.K., Chulkov V.S., Tarasova O.A., Sinitsyn S.P.

Federal State budgetary educational institution «South Ural State medical University» of the Ministry of Healthcare of Russia, Chelyabinsk
The purpose of the study is to evaluate the relationship of hemostasis rates, adipokines levels, renin-angiotensin system genes polymorphisms and target organ damage in young patients with hypertension and abdominal obesity. Material and methods. The study included 251 persons. A comprehensive assessment of the relationship of the hemostasis system, adipokines, polymorphisms of the genes of the renin-angiotensin system with the state of the target organ damage in young patients with hypertension and abdominal obesity has been carried out. Results. In patients aged 18-44 years with hypertension and abdominal obesity a higher levels of leptin, fibrinogen, plasminogen activator inhibitor type 1 and an inhibitor of the tissue factor pathway were found. A higher frequencies of M-allele of T174M and T-allele of M235T polymorphisms of angiotensinogen gene and C-allele of A1166C polymorphism of angiotensin II receptor gene were detected in association with target organ damage in young patients with hypertension and abdominal obesity. Conclusion. The above features of hemostasis, adipokines, and the prevalence of allelic variants of renin-angiotensin system genes make it possible to expand the understanding of pathogenetic mechanisms of the development of the metabolic syndrome at a young age.
Keywords: abdominal obesity, renin-angiotensin system, adipokines, left ventricular hypertrophy, hemostasis, hypertension
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About the Autors

Vladislav S. Chulkov, assistant of the faculty therapy Department of South Ural State medical University. Address: 454092, Chelyabinsk, 64 Vorovsky str. E-mail: vlad.chulkov.1989@mail.ru
Natalya K. Vereina, MD, PhD, professor of the faculty therapy Department of South Ural State medical University. Address: 454092, Chelyabinsk, 64 Vorovsky str. E-mail: vereinanata@yandex.ru
Vasilii S. Chulkov, MD, PhD, associated professor of the faculty therapy Department of South Ural State medical University. Address: 454092, Chelyabinsk, 64 Vorovsky str. E-mail: vschulkov@rambler.ru
Olesya Al. Tarasova, senior laboratory assistant of the faculty therapy Department of South Ural State medical University. Address: 454092, Chelyabinsk, 64 Vorovsky str. E-mail: Tarasova.o.a@bk.ru
Sergei P. Sinitsyn, MD, PhD, professor, head of the faculty therapy Department of South Ural State medical University. Address: 454092, Chelyabinsk, 64 Vorovsky str. E-mail: sinitsinsp@lenta.ru


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