Obstructive pulmonary diseases and disorders of carbohydrate metabolism: hospital patients hypoglycemia is focused on


DOI: https://dx.doi.org/10.18565/therapy.2019.6.143-150

Varvarina G.N., Makarova E.V., Plastinina S.S., Milyutina M.Y., Menkov N.V., Saltsev S.G.

Privolzhsky research medical University of the Ministry of Healthcare of Russia, Nizhny Novgorod
The relevant aspects of hospital hypoglycemia (acute, stressful), which often becomes evident with the worsening of obstructive pulmonary diseases – 91% of patients have diabetes mellitus type 2 and 63% of patients didn’t have any malfunctions of carbohydrate metabolism earlier, are considered in the review. Modern interpretation of the hospital hypoglycemia’s concept, risk’s factors and the pathogenetic way of its formation among this patients’ category are submitted. We have paid much attention to the role of neuroendocrine and inflammatory stressful return, hypoxia, acidosis, medicines. According to the analysis of retrospective and cohort research for the last years, the hospital hypoglycemia’s influence on increasing the cases of bad outcome is shown – long time hospitalization and death of the patients with obstructive pulmonary diseases. Few controversial facts about the forecasting meaning of hospital hypoglycemia in the origin of diabetes mellitus type 2 development are submitted.
Keywords: hospital hypoglycemia, bronchial asthma, chronic obstructive pulmonary disease, diabetes mellitus type 2
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Literature


  1. Чучалин А.Г. Пульмонология. Национальное руководство. Краткое издание. М.: ГЭОТАР-Медиа. 2014. 800 с.

  2. Сhuchalin A.G. Chronic respiratory diseases and risk factors in 12 regions of the Russian Federation. International Journal of COPD. 2014; 9: 963–74.

  3. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention (Updated 2018). [Electronic resource]. URL: http://ginasthma.org. Access: 11.05.2018

  4. https://www.who.int

  5. Global Strategy for the Diagnosis, Management and Prevention of COPD. Global Initiative for Chronic Obstructive Lung Disease (GOLD) (Updated 2018). [Electronic resource]. http://goldcopd.org. Access: 11.05.2018

  6. https://www.who.int/respiratory/asthma/scope/en

  7. Health topics. [Electronic resource]. World Health Organization. URL: http://www.who.int. Access: 11.05.2018.

  8. Whiting D.R., Guariguata L., Weil C. et al. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 2011; 94 (3): 311–21.

  9. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. 9-й выпуск. Под ред. И.И. Дедова, М.В. Шестаковой, А.Ю. Майорова. М., 2019. 211 с.

  10. Дедов И.И., Шестокова М.В, Галстян Г.Р. Распространенность СД 2 типа у взрослого населения России (исследование NATION). Сахарный диабет. 2016; 19(20): 104–12.

  11. Ромашов Б.Б., Полякова Н.В. Особенности патогенеза, клиники и лечения сочетания хронической обструктивной болезни легких и сахарного диабета. Молодой ученый. 2015; 13: 310–14.

  12. Couillard A., Veale D., Muir J.F. Comorbidities in COPD: a new challenge in clinical practice. Rev Pneumol Clin. 2011; 67(3): 143–53.

  13. Glaser S., Kruger S., Merkel M. et al. Chronic obstructive pulmonary disease and diabetes mellitus: а systematic review of the literature. Respiration. 2015; 89: 253–64.

  14. Rogliani Р., Calzetta L., Segreti A., Barrile A., Cazzola M. Diabetes among outpatients with COPD attending a university hospital. Acta Diabetologica. 2014; 51(6): 933–40.

  15. Rabe K.F., Wedzicha J.A., Wouters E.F.M. COPD and comorbidity. Eur. Respir. Soc. Monograph. 2013; 59.

  16. Бельских Э.С. Урясьев О.М., Куликов С.А. Распространенность коморбидных состояний у пациентов с бронхиальной астмой. Материалы ежегодной научной конференции рязанского государственного медицинского университета им. акад. И.П. Павлова. 2016; 232–35.

  17. Урясьев О.М. Бронхиальная астма и коморбидная кардиальная патология: частота и клинико-функциональные особенности. Земский врач. 2013; 3(20): 22–27.

  18. Еременко Г.В. Особенности течения бронхиальной астмы у больных с сопутствующим сахарным диабетом. Проблемы эндокринной патологии. 2015; 2(52): 22–27.

  19. Diabetes care in the hospital: standards of medical care in diabetes 2018. American Diabetes Association. Diabetes Care. 2018; 41(Suppl. 1): 144–51.

  20. Umpierrez G.E., Hellman R., Korytkowski M.T. et al. Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2012; 97(1): 16–38.

  21. Koskela H.O., Salonen P.H., Romppanen J., Niskane L. A history of diabetes but not hyperglycaemia during exacerbation of obstructive lung disease has impact on long-term mortality: a prospective, observational cohort study. BMJ Open. 2015; 5(1): e006794.

  22. Pittas A.G., Siegel R.D., Lau J. Insulin therapy and in-hospital mortality in critically ill patients: systematic review and meta-analysis of randomized controlled trials. JPEN Journal of parenteral and enteral nutrition. 2006; 30(2): 164–72.

  23. Nagham J., Edriss H., Islam E., Nugent K. The association between blood glucose levels and hospital outcomes in patients admitted with acute exacerbations of chronic obstructive pulmonary disease. The Southwest Respiratory and Critical Care Chronicles. 2014; 2(7); 1–11.

  24. Pallayova M., Lazurova I., Donic V. Hypoxic damage to pancreatic beta cells – the hidden link between sleep apnea and diabetes. Med Hypotheses. 2011; 77(5): 930–34.

  25. Tamez-Perez H., Quintanilla-Flores D., Rodriguez-Gutierrez R. et al. Steroid hyperglycemia: Prevalence, early detection and therapeutic recommendations: а narrative review. World J Diabetes. 2015; 6(8): 1073–81.

  26. Пластинина С.С., Вахламов В.А., Милютина М.Ю., Варварина Г.Н. Качество выявления нарушений углеводного обмена и роль исследования гликированного гемоглобина в диагностике сахарного диабета 2-го типа у больных с бронхообструктивными заболеваниями легких. Медицинский альманах. 2017; 6 (51):119–122.

  27. Fathallah N., Slim R., Larif S. et al. Drug-induced hyperglycaemia and diabetes. Drug Saf. 2015; 38(12): 1153–68.

  28. Сорокина Ю.А., Занозина О.В., Ловцова Л.В., Столярова В.В. с соавт. Гипогликемия и гипергликемия: потенциальные риски полипрагмазии при сахарном диабете 2-го типа в госпитальных условиях. Медицинский совет. 2018; 4: 112–115.

  29. Younk L.M., Lamos E.M., Davis S.N. The cardiovascular effects of insulin. Expert opinion on drug safety. 2014; 13(7): 955–66. doi:10.1517/14740338.2014.919256

  30. Mirrakhimov A.E. Chronic obstructive pulmonary disease and glucose metabolism: a bitter sweet symphony. Cardiovasc Diabetol. 2012; 11: 132.

  31. Yang C.J., Liao W.I., Tang Z.C. et al. Glycated hemoglobin A1c-based adjusted glycemic variables in patients with diabetes presenting with acute exacerbation of chronic obstructive pulmonary diseas. Int J Chron Obstruct Pulmon Dis. 2017; 12: 1923–32.

  32. Burt M.G., Roberts G.W., Aguilar-Loza N.R. et al. Relationship between glycaemia and length of hospital stay during an acute exacerbation of chronic obstructive pulmonary disease . Intern Med J. 2013; 43(6): 721–24.

  33. McAllister D.A., Hughes K.A, Lone N. et al. Stress hyperglycaemia in hospitalized patients and their 3-year risk of diabetes: a Scottish retrospective cohort study. PLoS Med. 2014; 11(8): e1001708

  34. Baker E.H., Baines D.L. Airway glucose homeostasis: a new target in the prevention and treatment of pulmonary infection. Chest. 2018; 153(2): 507–14.

  35. Alsayed S., Marzouk S., Mousa E., Ragab A. Bronchial aspirates glucose level as indicator for methicillin-resistant Staphylococcus aureus (MRSA) in intubated mechanically ventilated patients. J Egypt Soc Parasitol. 2014; 44(2): 381–88

  36. Garnett J.P. et al. Proinflammatory mediators disrupt glucose homeostasis in airway surface liquid. J Immunol. 2012; 189(1): 373–80.

  37. Hanberger H., Walther S., Leone M. et al. Increased mortality associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in the intensive care unit: results from the EPIC II study. Int J Antimicrob Agents. 2011; 38(4): 331–35.

  38. Lee A.S., Huttner B., Harbarth S. Control of methicillin-resistant Staphylococcus aureus. Infect Dis Clin North Am. 2011; 25: 155–79.

  39. Kinney G.L., Baker E.H., Klein O.L. et al. Pulmonary predictors of incident diabetes in smokers. Chronic Obstr Pulm Dis. 2016; 3(4): 739–47.

  40. Islam E.A., Limsuwat C., Nantsupawat T. et al. The association between glucose levels and hospital outcomes in patients with acute exacerbations of chronic obstructive pulmonary disease. Ann Thorac Med. 2015; 10(2): 94–99.

  41. Marik P.E., Bellomo R. Stress hyperglycemia: an essential survival response! Crit Care. 2013; 17(2): 305.

  42. Kasirye Y., Simpson M., Mamillapalli C.K., Epperla N., Liang H., Yale S.H. et al. Association between blood glucose level and outcomes in patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease. WMJ. 2013; 112(6): 244–49.


About the Autors

Galina N. Varvarina, MD, professor of the Department of propedeutics of internal diseases of Privolzhsky research medical University of the Ministry of Healthcare of Russia. Address: 603011, Nizhny Novgorod, 43 Chongarskaya str. Tel.: +7 (831) 216-32-68. Е-mail: оlvarvarin@yandex.ru
Ekaterina V. Makarova, MD, associate professor, the Head of the Department of propedeutics of internal diseases of Privolzhsky research medical University of the Ministry of Healthcare of Russia. Address: 603005, Nizhny Novgorod, 20 Semashko str. Tel.: +7 (831) 419-61-94. Е-mail: e.makarova@mail.ru
Svetlana S. Plastinina, PhD, associate professor of the Department of propedeutics of internal diseases of Privolzhsky research medical University of the Ministry of Healthcare of Russia. Address: 603155, Nizhny Novgorod, 1 Verkhne-Volzhskaya quay. Tel.: +7 (831) 218-19-50. Е-mail: plastininaswetlana@yandex.ru
Marina Yu. Milyutina, assistant of the Department of propedeutics of internal diseases of Privolzhsky research medical University of the Ministry of Healthcare of Russia. Address: 603005, Nizhny Novgorod, 20 Semashko str. Tel.: +7 (831) 419-61-94. Е-mail: marinamilutina@bk.ru
Nikolay V. Menkov, PhD, associate professor of the Department of propedeutics of internal diseases of Privolzhsky research medical University of the Ministry of Healthcare of Russia. Address: 603011, Nizhny Novgorod, 43 Chongarskaya str. Tel.: +7 (831) 216-32-68
Sergey G. Saltsev, PhD, associate professor of the Department of propedeutics of internal diseases of Privolzhsky research medical University of the Ministry of Healthcare of Russia. Address: 603011, Nizhny Novgorod, 43 Chongarskaya str. Tel.: +7 (831) 216-32-68. Е-mail: ims@list.ru


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