Influence of the thyroid gland functional condition at the risk of gestational diabetes mellitus development


DOI: https://dx.doi.org/10.18565/therapy.2020.8.23-29

Ushanova F.O., Demidova T.Yu., Abdukha­midova Kh.K., Enkhtaivan B., Perekhodov S.N.

1) N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia, Moscow; 2) V.P. Demikhov City Clinical Hospital of Healthcare Department of Moscow
The aim is to study the features of thyroid gland functional condition of in pregnant women with gestational diabetes mellitus (GDM) and to assess the prevalence of hypothyroidism in this group of patients.
Material and methods. A retrospective analysis of the outpatient cards of 779 pregnant women aged 19–46 years for 2019 was carried out In V.P. Demikhov City Clinical Hospital.
Results. GDM was diagnosed in 599 patients, 114 (19,03%) of them had symptomatic hypothyroidism. In 19 (3,17%) patients with GDM, obesity and hypothyroidism were combined. In 19 (3,17%) cases in females with GDM, subclinical hypothyroidism developed as a result of autoimmune thyroiditis, i.e. a positive antibody titer was detected. In 46 pregnant women, the carriage of antibodies to thyroid peroxidase (AB TPO) was detected with a normal level of thyroid stimulating hormone (TSH). In 177 pregnant women with elevated TSH levels, the diagnosis of GDM was not confirmed.
Conclusion. From the data of the analysis it follows that GDM occurs more often in females over 30 years of age who are overweight at the time of gestation. GDM in this group of pregnants is often combined with hypothyroidism and AT TPO carriage. Having these conditions, patients had a significantly higher risk of GDM developing comparatively with euthyroid women. Further research concening the relationship between hypothyroidism and GDM is needed.
Keywords: free triiodothyronine, free thyroxine, autoantibodies to thyroid peroxidase, thyroid stimulating hormone, thyroid gland, autoimmune thyroiditis, gestational diabetes mellitus, hypothyroidism
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About the Autors

Fatima O. Ushanova, assistant of the Department of endocrinology, faculty of general medicine of N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str. Tel.: +7 (925) 011-10-10. E-mail: fati_2526@mail.ru
Tatyana Yu. Demidova, MD, professor, head of the Department of endocrinology, faculty of general medicine of N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 109263, Moscow, 4/1 Shkuleva Str. E-mail: t.y.demidova@gmail.com. ORCID: 0000-0001-6385-540X
Humora K.K. Abdukhamidova, 6th year student of the faculty of general medicine of N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str.
Baigal Enkhtaivan, 6th year student of the faculty of general medicine of N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia. Address: 117997, Moscow, 1 Ostrovityanova Str.
Sergei N. Perekhodov, professor, chief physician of V.P. Demikhov City Clinical Hospital of Healthcare Department of Moscow. Address: 109263, Moscow, 4 Shkuleva Str. E-mail: gkb68@zdrav.mos.ru


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