Hyperammonemia in the practice of a therapist and cardiologist: theoretical and practical significance


DOI: https://dx.doi.org/10.18565/therapy.2021.5.157-162

Khlynova O.V., Skachkova V.V.

Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia
Abstract. Hyperammonemia (HAM) is a metabolic disorder caused by excessive amounts of ammonia in the blood as a result of inherited, acquired and even functional causes of ammonia synthesis and excretion. Currently, the clinical-laboratory symptom complex (syndrome) of HAM is associated by clinicians predominantly with severe liver pathology, including cirrhotic and non-cyrrhotic forms of disease. However, in some cases, HAM may also have extrahepatic developmental genesis. The article presents an analysis of domestic and foreign sources of literature on data demonstrating the importance of studying the phenomenon of HAM in cardiological practice. Taking into account the pathogenetic and pathophysiological mechanisms of formation, GAM can be studied not only in hepatology, but also in clinical cardiology, as well as preventive and age-associated medicine.
Keywords: pathology of cardiovascular system, hyperammonemia, heart failure
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About the Autors

Olga V. Khlynova, MD, professor, corresponding member of RAS, head of the Department of hospital therapy and cardiology, Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia. Address: 614990, Perm, 85 Pushkina Str. E-mail: olgakhlynova@mail.ru. ORCID: 0000-0003-4860-0112
Valeria V. Skachkova, resident physician of the Department of hospital therapy and cardiology, Academician E.A. Wagner Perm State Medical University of the Ministry of Healthcare of Russia. Address: 614990, Perm, 85 Pushkina Str. E-mail: valerya1skachkova@yandex.ru


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