Русский
The role of apoptosis-regulating ligand-receptor Fas and TNF-α systems ratios in the ischemic stroke clinical manifestations formation
DOI: https://dx.doi.org/10.18565/therapy.2022.9.13-21
Sergeeva S.P., Savin A.A., Litvitskiy P.F., Savin L.A., Manasova Z.Sh., Dzhumagulova D.D., Breslavich I.D.
1) I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University); 2) A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia
Objective: to reveal the role of the ligand-receptor ratios of the Fas and TNF-α systems regulating apoptosis in the formation of clinical manifestations of IS.
Material and methods. The content of sFas, sFasL, TNF-α, sTNF-R1, IL-6 was detected in the blood on days 1, 7, and 21 by ELISA in 155 patients with LMBA or RMBA IS, as well as Fas-positive lymphocytes by flow cytofluorometry. Neurological suffering was assessed using the NIHSS.
Results. A significant increase in blood concentrations of sFasL, sFas and TNF-α was shown compared to the control.
Conclusion. In stroke manifestation the role of the Fas system is associated with inflammatory response; at the end of the acute period, with the dominance of adaptive mechanisms and processes of neuroplasticity.
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About the Autors
Svetlana P. Sergeeva, PhD in Medicine, associate professor of the Department of pathophysiology, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya Str. E-mail: svetlanapalna@mail.ru.
ORCID: https://orcid.org/0000-0002-0083-1213. Scopus Author ID: 7005881603. ResearcherID: P-2450-2015
Alexey A. Savin, Dr. med. habil., professor of the Department of nervous diseases, A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya Str. E-mail: a9165383509@gmail.com. ORCID: https://orcid.org/0000-0002-6340-8623
Petr F. Litvitsky, Dr. med. habil., professor, corresponding member of RAS, head of the Department of pathophysiology, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya Str. E-mail: litvicki@mma.ru.
ORCID: https://orcid.org/0000-0003-0151-9114
Leonid A. Savin, PhD in Medicine, assistant at the Department of nervous diseases, A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia. Address: 127473, Moscow, 20/1 Delegatskaya Str. E-mail: lasavin@mail.ru. ORCID: https://orcid.org/0000-0002-3557-8780
Zaripat Sh. Manasova, PhD in Medicine, associate professor of the Department of pathophysiology, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya Str. E-mail: zmanasova@yandex.ru.
ORCID: https://orcid.org/0000-0002-3003-4362
Dzhennet D. Dzhumagulova, student of I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya Str. E-mail: Butri78@mail.ru
Ilya D. Breslavich, assistant at the Department of pathophysiology, I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University). Address: 119991, Moscow, 8/2 Trubetskaya Str. E-mail: br_i@inbox.ru. ORCID: https://orcid.org/0000-0002-9321-9102
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