Русский
Indicators of systemic inflammation and state of the cardiovascular system in patients with chronic kidney disease
DOI: https://dx.doi.org/10.18565/therapy.2023.3.15-20
Zhmurov D.V., Zhmurov V.A., Petrov I.M., Petelina T.I., Gapon L.I., Yaroslavskaya E.I., Petrova Yu.A., Oskolkov S.A., Zhmurova E.A., Vanuyto E.Ya., Ermakova A.A., Ermakova P.A.
1) Tyumen State Medical University of the Ministry of Healthcare of Russia; 2) Tyumen Cardiological Research Center – a branch of Tomsk National Research Medical Center of the Russian Academy of Sciences
The aim of the study is to characterize the indicators of systemic inflammation in correlation with cardiovascular system changes in CKD patients.
Material and methods. 150 patients with CKD were examined. All participants of the research were divided into 2 groups: patients with CKD without cardiovascular disease (CVD, n=75); and CKD patients with CVD (n=75). The groups differed significantly in SBP, DBP, HR, BMI (p <0,001). Special research methods included the determination of the level of interleukins (IL-1, IL-6, IL-8), TNF-α, fibroblast proliferation factor (TgFb1) and highly sensitive CRP.
Results. In examined patients with CKD and CVD, there was found an increase in the level of IL-1, IL-6, TNF-α, as well as a tendency for increase of TgFb1 level and decrease of IL-8 comparatively with CKD patients without CVD. It was fixed an increase of cystatin C level and microalbuminuria among patients with CVD comparatively with the group without CVD.
Conclusion. Pathological processes laying in CKD basis are accompanied by an increase in the level of pro-inflammatory cytokines. The results obtained can serve as a prerequisite for improving the pathogenetic therapy of CKD with cardiovascular manifestations.
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About the Autors
Denis V. Zhmurov, PhD in Medical Sciences, associate professor of the Department of propaedeutics of internal diseases, Tyumen State Medical University of the Ministry of Healthcare of Russia. Address: 625023, Tyumen, 54 Odesskaya Str. E-mail: zhmdenis@yandex.ru. ORCID: https://orcid.org/0000-0003-3167-5310
Vladimir A. Zhmurov, MD, professor, head of the Department of propaedeutics of internal diseases, Tyumen State Medical University of the Ministry of Healthcare of Russia. Address: 625023, Tyumen, 54 Odesskaya Str. E-mail: zhmurovva@yandex.ru. ORCID: https://orcid.org/0000-0002-7228-6197
Ivan M. Petrov, MD, associate professor, head of the Department of medical informatics and biological physics with the UNESCO bioethics network section, Tyumen State Medical University of the Ministry of Healthcare of Russia. Address: 625023, Tyumen, 54 Odesskaya Str.
Tatyana I. Petelina, MD, leading researcher at the Department of arterial hypertension and coronary insufficiency of the scientific Department of clinical cardiology, Tyumen cardiological Research Center – a branch of Tomsk National Research Medical Center of the Russian Academy of Sciences. Address: 625026, Tyumen, 111 Melnikaite Str.
Lyudmila I. Gapon, MD, professor, head of the scientific Department of clinical cardiology, scientific director of the Department of arterial hypertension, Tyumen Cardiological Research Center – a branch of Tomsk National Research Medical Center of the Russian Academy of Sciences. Address: 625026, Tyumen, 111 Melnikaite Str.
Elena I. Yaroslavskaya, MD, head of the Laboratory of instrumental diagnostics, Tyumen Cardiological Research Center – a branch of TOMSK NATIONAL RESEARCH MEDICAL CENTER of the Russian Academy of Sciences. Address: 625026, Tyumen, 111 Melnikaite Str.
Yulianna A. Petrova, PhD in Medical Sciences, associate professor of the Department of propaedeutics of internal diseases, Tyumen State Medical University of the Ministry of Healthcare of Russia. Address: 625023, Tyumen, 54 Odesskaya Str.
Sergey A. Oskolkov, MD, professor of the Department of propaedeutics of internal diseases, Tyumen State Medical University of the Ministry of Healthcare of Russia. Address: 625023, Tyumen, 54 Odesskaya Str.
Ekaterina A. Zhmurova, 2nd year attending physician at the Department of internal medicine, polyclinic therapy and family medicine, Tyumen State Medical University of the Ministry of Healthcare of Russia. Address: 625023, Tyumen, 54 Odesskaya Str.
Evgeniy Ya. Vanuito, postgraduate student of the Department of propaedeutics of internal diseases, Tyumen State Medical University of the Ministry of Healthcare of Russia. Address: 625023, Tyumen, 54 Odesskaya Str.
Anna A. Ermakova, institute of clinical medicine, 6th year student, Department of propaedeutics of internal diseases, Tyumen State Medical University of the Ministry of Healthcare of Russia. Address: 625023, Tyumen, 54 Odesskaya Str.
Polina A. Ermakova, institute of clinical medicine, 6th year student, Department of propaedeutics of internal diseases, Tyumen State Medical University of the Ministry of Healthcare of Russia. Address: 625023, Tyumen, 54 Odesskaya Str.
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