Русский
Intradialysis hypertension: Focus at high dialysis clearance of antihypertensive medicines
DOI: https://dx.doi.org/10.18565/therapy.2023.3.28-35
Tokareva A.S., Borovkova N.Yu., Lineva N.Yu., Mazhukhina A.A., Mironov M.A.
1) Privolzhsky Research Medical University of the Ministry of Healthcare of Russia, Nizhny Novgorod; 2) N.A. Semashko Nizhny Novgorod Regional Clinical Hospital
The aim of the research is to study the nature of antihypertensive therapy in hemodialysis patients, to assess the IDH frequency and to identify the most significant predictors of its development.
Material and methods. A retrospective study of 131 outpatient cards of dialysis patients was carried out. Data of performing medicamentous therapy were recorded with an emphasis on the dialyzability of the medicines used. Statistical analysis was performed using the IBM SPSS Statistics 26 application package.
Results. IDH occurred in 60% of dialysis patients and was associated with the use of beta-blockers (p=0,015), moxonidine (p=0,001), and highly dialysable medicines (p <0,0001). In multifactor model, the use of beta-blockers has lost its significance, giving way to highly dialysable antihypertensive medicines and moxonidine.
Conclusion. Analysis of the characteristics of drug therapy demonstrated the predominance of highly dialyzable medicines in the treatment of patients at hemodialysis. Use of medicines with high dialysis clearance was associated with an increased IDH incidence (OR 5,585; 95% CI: 2,49–12,54; p <0,0001).
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About the Autors
Anastasia S. Tokareva, assistant at the Department of hospital therapy and general medical practice named after V.G. Vogralik, Privolzhsky Research Medical University of the Ministry of Healthcare of Russia. Address: 603005, Nizhny Novgorod, 10/1 Minina and Pozharskogo Sq. E-mail: toktokareva@gmail.com.
ORCID: https://orcid.org/0000-0003-0640-6848
Natalya Yu. Borovkova, MD, associate professor, professor of the Department of hospital therapy and general medical practice named after V.G. Vogralik, Privolzhsky Research Medical University of the Ministry of Healthcare of Russia. Address: 603005, Nizhny Novgorod, 10/1 Minina and Pozharskogo Sq. E-mail: borovkov-nn@mail.ru. ORCID: https://orcid.org/0000-0001-7581-4138
Natalya Yu. Lineva, head of the Department of dialysis and gravitational blood surgery, N.A. Semashko Nizhny Novgorod Regional Clinical Hospital. Address: 603126, Nizhny Novgorod, 190 Rodionova Str. E-mail: lineva_natalja@rambler.ru. ORCID: https://orcid.org/0000-0002-2900-5986
Alina A. Mazhukhina, 6th year student of the Faculty of general medicine, Privolzhsky Research Medical University of the Ministry of Healthcare of Russia. Address: 603005, Nizhny Novgorod, 10/1 Minina and Pozharskogo Sq. E-mail: kudryashovamargo@yandex.ru
Mikhail A. Mironov, 6th year student of the Faculty of general medicine, Privolzhsky Research Medical University of the Ministry of Healthcare of Russia. Address: 603005, Nizhny Novgorod, 10/1 Minina and Pozharskogo Sq. E-mail: mironovdoctor@gmail.com
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