Сартаны: от коррекции артериальной гипертензии к управлению сердечно-сосудистым риском


DOI: https://dx.doi.org/10.18565/therapy.2019.7.112-119

В.С. Чулков, Е.А. Ленец

ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России, г. Челябинск
Блокаторы AT1-рецепторов – один из четырех классов препаратов для начальной терапии артериальной гипертензии. Эти препараты используются также в лечения хронической сердечной недостаточности и хронической болезни почек. Фимасартан – девятый и последний сартан, представляющий собой пиримидин-4(3H)-ОН производное лозартана, в котором заменено кольцо имидазола. Фимасартан является селективным антагонистом рецептора 1 типа ангиотензина II, что обеспечивает неконкурентное, непреодолимое (необратимое) связывание с этим рецептором. Доклинические исследования показали некоторые потенциальные плейотропные эффекты фимасартана, включая противовоспалительный и органопротективный. Во второй фазе клинических исследований при назначении в дозе 60–120 мг однократно фимасартан продемонстрировал 24-часовой антигипертензивный эффект и благоприятный профиль безопасности. В третьей фазе клинических исследований фимасартан по выраженности антигипертензивного эффекта не уступал лозартану и кандесартану и превосходил валсартан.
Ключевые слова: фимасартан, эффективность, артериальная гипертензия, безопасность, лечение
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Об авторах / Для корреспонденции

Василий Сергеевич Чулков, д.м.н., профессор кафедры факультетской терапии ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России. Адрес: 454092, г. Челябинск, ул. Воровского, д. 64. E-mail: vschulkov@rambler.ru
Елизавета Анатольевна Ленец, лаборант кафедры факультетской терапии ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России. Адрес: 454092, г. Челябинск, ул. Воровского, д. 64. E-mail: liza.lenetz@yandex.ru


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