Chronic brain ischemia in youthful age persons with undifferentiated connective tissue dysplasia


DOI: https://dx.doi.org/10.18565/therapy.2022.10.31-40

Maltseva I.V., Sheremetyeva I.I., Kotovschikova E.F., Stroganov A.E., Lukinov V.L.

1) Altai State Medical University of the Ministry of Healthcare of Russia, Barnaul; 2) Institute of Computational Mathematics and Mathematical Geophysics of the Siberian branch of the Russian Academy of Sciences, Novosibirsk
Abstract. Factors unfavorable for the development of chronic cerebral ischemia (CCI), such as arterial hypotension and cardiac arrhythmias due to vegetative dysregulation, blood flow disturbances in brachiocephalic vessels, anemic syndrome are often found in people with undifferentiated connective tissue dysplasia (UCTD). Clinically, the early stages of CCI occur in the form of cognitive and psychovegetative disorders, which are also UCTD characteristics. Such a biomarker as antibodies to the NR-2 peptide (NR2-At) determines the past cerebral ischemia.
The aim: to study the correlation of UCTD with cerebral ischemia development in youthful age people.
Material and methods. The study involved 80 persons aged 18–22 studying at the ASMU. According to the content of NR2-At, 2 groups were separated: with normal (control group, n=23) and increased (comparison group, n=57) titer of this marker. A general clinical and neuropsychological examination was carried out, markers of anemia, inflammation, neurotrophism, neurodegeneration were studied, duplex scanning of brachiocephalic vessels, electroencephalography were performed.
Results. The marker of cerebral ischemia was elevated in 71% of students. Autonomic dysfunction, asthenia, anxiety, depression, headache index were higher in the comparison group. A significant increase in NR2-At was found in the group with severe UCTD. Presence of UCTD, headaches, a decrease in red blood indexes, and female sex were the predictors associated with an increase in the chances of cerebral ischemia developing.
Conclusion. A correlation between the development of cerebral ischemia and severe UCTD in youthful age people has been established, so the dysplastic process correction can become an important part in prevention and treatment of CCI and non-psychotic mental disorders. Obtained results allow us to consider pronounced UCTD as an independent risk factor for the development of CCI.
Keywords: neuron-specific enolase (NSE), brain-derived neurotrophic factor (BDNF), antibodies to NR-2 peptide, autonomic dysfunction syndrome, undifferentiated connective tissue dysplasia, chronic cerebral ischemia, depression, anxiety, headache
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About the Autors

Irina V. Maltseva, assistant at the Department of propaedeutics of internal diseases named after prof. Z.S. Barkagan, Altai State Medical University of the Ministry of Healthcare of Russia. Address: 656038, Barnaul, 40 Lenina Avenue. E-mail: ibogd2009@rambler.ru. ORCID: https://orcid.org/0000-0002-4247-2052
Irina I. Sheremetyeva, Dr. med. habil., professor, Rector, head of the Department of psychiatry, medical psychology and narcology with the course of FVE, Altai State Medical University of the Ministry of Healthcare of Russia. Address: 656038, Barnaul, 40 Lenina Avenue. E-mail: rector@agmu.ru. ORCID: https://orcid.org/0000-0001-8513-9869
Elena F. Kotovshchikova, Dr. med. habil., professor, head of the Department of propaedeutics of internal diseases named after prof. Z.S. Barkagan, Altai State Medical University of the Ministry of Healthcare of Russia. Address: 656038, Barnaul, 40 Lenina Avenue. E-mail: kotov-l@mail.ru. ORCID: https://orcid.org/0000-0002-3246-5609
Alexander E. Stroganov, Dr. med. habil., associate professor, professor of the Department of psychiatry, medical psychology and narcology with course of FVE, Altai State Medical University of the Ministry of Healthcare of Russia. Address: 656038, Barnaul, 40 Lenin Prospect St. E-mail: jazz200261@mail.ru. ORCID: https://orcid.org/0000-0002-1791-7996
Vitaly L. Lukinov, candidate of physical and mathematical sciences, senior researcher, head of the Laboratory for numerical analysis of stochastic differential equations, Institute of Computational Mathematics and Mathematical Geophysics of the Siberian branch of the Russian Academy of Sciences. Address: 630090, Novosibirsk, 6 Akademika Lavrentieva Avenue. E-mail: vitaliy.lukinov@gmail.com. ORCID: https://orcid.org/0000-0002-3411-508X


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